drugset / Trial / NCT00000776

Dexamethasone in Cryptococcal Meningitis

NCT00000776

Double-blindTreatment

Summary

To evaluate the effect of corticosteroids on reducing elevated intracranial pressure in cryptococcal meningitis. To evaluate the safety of corticosteroids in patients with cryptococcal meningitis and intracranial hypertension. In AIDS patients with cryptococcal meningitis, a correlation has been found between early death and elevated intracranial pressure. Since dexamethasone has been found to reduce intracranial pressure resulting from other forms of meningitis, it may be of benefit in AIDS patients with cryptococcal meningitis.

Timeline

Start
Primary completion
Completion
1996-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Dexamethasone Small molecule
Background Amphotericin B Unknown
Background Fluconazole Small molecule
Background Flucytosine Small molecule