Chemotherapy in Treating Patients With Advanced Sarcoma

Phase 2 Completed 20 enrolled Swiss Cancer Institute

NaSingle-groupOpen-labelTreatment

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy consisting of ifosfamide and doxorubicin in patients with advanced sarcoma.

Timeline

Start: 1993-01
Primary completion: 1995-09
Completion: 1995-09

Publications

Results Leyvraz S, Zweifel M, Jundt G, Lissoni A, Cerny T, Sessa C, Fey M, Dietrich D, Honegger HP; Swiss Group for Clinical Cancer Research. Long-term results of a multicenter SAKK trial on high-dose ifosfamide and doxorubicin in advanced or metastatic gynecologic sarcomas. Ann Oncol. 2006 Apr;17(4):646-51. doi: 10.1093/annonc/mdl020. Epub 2006 Feb 24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Doxorubicin	Other / unclassified	25 mg/m2	Intravenous
Subject	Ifosfamide	Small molecule	10 g/kg	Intravenous
Background	filgrastim	Protein / enzyme biologic	—	Subcutaneous

Chemotherapy in Treating Patients With Advanced Sarcoma

Summary

Timeline

Publications

Drugs

Indications