Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer

Phase 3 Terminated 2108 enrolled Gynecologic Oncology Group Eastern Cooperative Oncology Group · collab National Cancer Institute (NCI) · collab SWOG Cancer Research Network · collab

RandomizedTreatment

Summary

RATIONALE: Estrogen replacement therapy may improve quality-of-life in postmenopausal women with endometrial cancer. It is not yet known whether estrogen replacement therapy will affect cancer recurrence. PURPOSE: Randomized double-blinded phase III trial to determine the effectiveness of estrogen replacement therapy in treating women who have stage I or stage II endometrial cancer.

Timeline

Start: 1997-06
Primary completion: 2006-07
Completion: —

Publications

Results Barakat RR, Bundy BN, Spirtos NM, Bell J, Mannel RS; Gynecologic Oncology Group Study. Randomized double-blind trial of estrogen replacement therapy versus placebo in stage I or II endometrial cancer: a Gynecologic Oncology Group Study. J Clin Oncol. 2006 Feb 1;24(4):587-92. doi: 10.1200/JCO.2005.02.8464.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	conjugated estrogens	Other / unclassified	—	Oral

Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer

Summary

Timeline

Publications

Drugs

Indications