drugset / Trial / NCT00003136
Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Epithelial Ovarian Cancer or Primary Peritoneal Cancer
NaSingle-groupOpen-labelTreatment
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. PURPOSE: Phase I/II trial to study the effectiveness of amifostine, carboplatin and cyclophosphamide, followed by peripheral stem cell transplantation, in treating patients with epithelial ovarian cancer or primary peritoneal cancer.
Timeline
- Start
- 1996-12
- Primary completion
- 2000-12
- Completion
- 2001-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Carboplatin | Small molecule | 1600 mg/m2 | — |
| Subject | Carboplatin | Small molecule | 1700 mg/m2 | — |
| Subject | Carboplatin | Small molecule | 1800 mg/m2 | — |
| Background | Cyclophosphamide | Other / unclassified | 40 mg/kg | Intravenous |
| Background | amifostine | Unknown | 910 mg/m2 | Intravenous |
| Background | filgrastim | Protein / enzyme biologic | — | — |