Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known whether giving procarbazine alone or with isotretinoin is more effective for recurrent primary malignant glioma. PURPOSE: Randomized phase III trial to compare the effectiveness of procarbazine alone or with isotretinoin in treating patients with recurrent primary malignant gliomas.

Timeline

Start

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Primary completion

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Completion

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Outcome

Outcome not reported

Stopped: “Study withdrawn.”

Drugs

Indications