drugset / Trial / NCT00003592
Methotrexate Compared With Paclitaxel in Treating Patients With Advanced Head and Neck Cancer
Phase 3
Completed
230 enrolled
Eastern Cooperative Oncology Group
National Cancer Institute (NCI) · collab
RandomizedTreatment
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether methotrexate or paclitaxel is more effective in treating patients with advanced head and neck cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of methotrexate with that of paclitaxel in treating patients who have advanced head and neck cancer that cannot be treated with cisplatin.
Timeline
- Start
- 1999-04-22
- Primary completion
- 2000-08
- Completion
- 2004-03-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Methotrexate | Small molecule | — | Intravenous |
| Subject | Paclitaxel | Small molecule | — | Intravenous |