drugset / Trial / NCT00003925
Combination Chemotherapy In Treating Patients With Advanced Cancer
Phase 1
Completed
36 enrolled
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI) · collab
Treatment
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of combining gemcitabine, fluorouracil-uracil and leucovorin in treating patients who have advanced cancer that has not responded to previous therapy.
Timeline
- Start
- 1998-05
- Primary completion
- 2007-08
- Completion
- 2007-08
Publications
- Results El-Rayes BF, Zalupski M, Shields AF, Manza SG, LoRusso P, Philip PA. A phase I study of gemcitabine and uracil-ftorfar (UFT)/leucovorin. Am J Clin Oncol. 2007 Apr;30(2):101-5. doi: 10.1097/01.coc.0000251223.98193.f4.
- Results Philip PA, Ibrahim D, Zalupski M, Arlauskas P, Shields A. Gemcitabine and UFT plus oral calcium folinate: phase I study. Oncology (Williston Park). 1999 Jul;13(7 Suppl 3):116-9.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Gemcitabine | Small molecule | 600 mg/m2 | Intravenous |
| Subject | Gemcitabine | Small molecule | 800 mg/m2 | Intravenous |
| Subject | Leucovorin | Small molecule | 30 mg | Oral |
| Subject | tegafur-uracil | Small molecule | 150 mg/m2 | Oral |
| Subject | tegafur-uracil | Small molecule | 200 mg/m2 | Oral |
| Subject | tegafur-uracil | Small molecule | 250 mg/m2 | Oral |