tegafur-uracil
Trials 13 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT00003925 | May 1998 → Aug 2007 | cancer of unknown primary site | Barbara Ann Karmanos Cancer Institute | Completed | No outcome recorded |
| Phase 1 | NCT00002801 | Apr 1996 → Dec 2003 | colorectal cancer | Memorial Sloan Kettering Cancer Center | Completed | No outcome recorded |
| Phase 25 trials | ||||||
| Phase 2 | NCT03121313 | Feb 2015 → May 2020 | oral cavity squamous cell carcinoma | Chang Gung Memorial Hospital | Unknown | No outcome recorded |
| Phase 2 | NCT01539018 | Jan 2012 → Jan 2015 | hepatocellular carcinoma | Egyptian Society of Liver Cancer | Terminated | No outcome recorded |
| Phase 2 | NCT01262274 | Dec 2010 → Jun 2013 | breast neoplasm | Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan | Terminated | No outcome recorded |
| Phase 2 | NCT00855881 | Dec 2008 → Dec 2014 | head and neck cancer | Mackay Memorial Hospital | Unknown | No outcome recorded |
| Phase 2 | NCT00005608 | Feb 2000 → Jun 2002 | breast cancer | Northwestern University | Terminated | No outcome recorded |
| Phase 34 trials | ||||||
| Phase 3 | NCT02944708 | Oct 2015 → Oct 2018 | nasopharyngeal carcinoma | Shanghai Proton and Heavy Ion Center | Unknown | No outcome recorded |
| Phase 3 | NCT02363400 | Dec 2014 → Dec 2021 | nasopharyngeal carcinoma | National Health Research Institutes, Taiwan | Terminated | No outcome recorded |
| Phase 3 | NCT00336947 | Apr 2006 → Mar 2012 | head and neck cancer | Yokohama City University | Unknown | No outcome recorded |
| Phase 3 | NCT00905047 | Nov 2005 → Jun 2010 | colorectal cancer | Centre Oscar Lambret | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT02887365 | Sep 2014 → Aug 2017 | malignant colon neoplasm | National Taiwan University Hospital | Unknown | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT02836977 | Mar 2016 → Mar 2017 | malignant colon neoplasm | Kaohsiung Medical University Chung-Ho Memorial Hospital | Unknown | No outcome recorded |
Also used as a comparator or background therapy in 6 trials
Evidence & citations 7 cited values
Every value below carries the sentence it was read from. 20 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | TEGAFUR URACIL | “Maintenance chemotherapy should use one of the regimens: S1 (40mg, twice a day for 14 days, every 3 weeks), capecitabine (1000mg/m\^2, twice a day for 14 days, every 3 weeks)...” NCT02944708 ↗20“The SACURA trial is a randomised-controlled study evaluating the superiority of 1-year adjuvant treatment with oral tegafur-uracil (UFT) to surgery alone for stage II colon cancer.” PMID 29677641 ↗ Apr 2018 “Tegafur/uracil treatment of mice with RENCA tumors has been shown to inhibit angiogenesis, leading to a significant prolongation of life span.” NCT00855881 ↗ “Xeloda or UFT (Tegafur-uracil) With Folinic Acid in Advanced or Metastatic Colorectal Cancer” NCT00905047 ↗ “Xeloda or UFT (Tegafur-uracil) With Folinic Acid in Advanced or Metastatic Colorectal Cancer” NCT00905047 ↗ “oral Tegafur-uracil” NCT02363400 ↗ |
| Known as | fluorouracil-uracil | “This is a dose-escalation study of fluorouracil-uracil (UFT).” NCT00002801 ↗ |
| Known as | UFT | “Uracil-tegafur (UFT), an oral fluoropyrimidine prodrug, is available commercially in Japan and in several other countries.” NCT00855881 ↗7“Xeloda or UFT (Tegafur-uracil) With Folinic Acid in Advanced or Metastatic Colorectal Cancer” NCT00905047 ↗ “Patients receive oral tegafur-uracil (UFT) once daily on days 1-21.” NCT00336947 ↗ “This is a dose-escalation study of fluorouracil-uracil (UFT).” NCT00002801 ↗ “metronomic tegafur-uracil (UFT)” NCT01262274 ↗ “Why Tegafur-uracil (UFT)?” NCT01539018 ↗ “Tegafur-uracil (UFT)” NCT00385970 ↗ |
| Known as | Uracil-tegafur | “Uracil-tegafur (UFT), an oral fluoropyrimidine prodrug, is available commercially in Japan and in several other countries.” NCT00855881 ↗ |
| Action | Inhibit | “The 5-FU metabolite FdUMP binds and inhibits the enzymatic activity of thymidylate synthase (TS)” NCT00855881 ↗ |
| Modality | Small molecule | “an oral fluoropyrimidine prodrug” NCT00855881 ↗ |
| Route | Oral | “patients receive oral UFT and oral leucovorin calcium (CF) 3 times a day on days 1-28.” NCT00002801 ↗ |