Combination Chemotherapy In Treating Patients With Metastatic or Unresectable Solid Tumors

Phase 1 Completed Mayo Clinic National Cancer Institute (NCI) · collab

Treatment

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I trial to determine the effectiveness of two different regimens of combination chemotherapy in treating patients who have metastatic or unresectable solid tumors.

Timeline

Start: 2000-01
Primary completion: 2003-06
Completion: 2003-06

Publications

Results Goetz MP, Erlichman C, Windebank AJ, Reid JM, Sloan JA, Atherton P, Adjei AA, Rubin J, Pitot H, Galanis E, Ames MM, Goldberg RM. Phase I and pharmacokinetic study of two different schedules of oxaliplatin, irinotecan, Fluorouracil, and leucovorin in patients with solid tumors. J Clin Oncol. 2003 Oct 15;21(20):3761-9. doi: 10.1200/JCO.2003.01.238. Epub 2003 Sep 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Irinotecan	Small molecule	75 mg/m2	Intravenous
Subject	Irinotecan	Small molecule	175 mg/m2	Intravenous
Subject	Leucovorin	Small molecule	20 mg/m2	Intravenous
Subject	Oxaliplatin	Small molecule	50 mg/m2	Intravenous
Subject	Oxaliplatin	Small molecule	85 mg/m2	Intravenous
Subject	fluorouracil	Small molecule	240 mg/m2	Intravenous
Subject	fluorouracil	Small molecule	320 mg/m2	Intravenous

Combination Chemotherapy In Treating Patients With Metastatic or Unresectable Solid Tumors

Summary

Timeline

Publications

Drugs

Indications