drugset / Trial / NCT00014443
Topotecan and Thalidomide in Treating Patients With Recurrent or Refractory Malignant Glioma
Non-randomizedSingle-groupOpen-labelTreatment
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Thalidomide may stop the growth of cancer by stopping blood flow to the tumor. PURPOSE: Phase I trial to study the effectiveness of combining topotecan and thalidomide in treating patients who have recurrent or refractory malignant glioma.
Timeline
- Start
- 2000-08
- Primary completion
- 2003-08
- Completion
- 2003-12
Outcome
Outcome not reported
Stopped (Enrollment): “Poor enrollment”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Thalidomide | Other / unclassified | — | Oral |
| Subject | Topotecan | Small molecule | — | Intravenous |