drugset / Trial / NCT00015041
Buprenorphine Dose Escalation Trial for Treatment of Non-Dependent Opiate Users - 2
Treatment
Summary
The purpose of this study is to evaluate the effect, pharmacokinetics and dose proportionality of buprenorphine when administered to non-dependent opiate users. 1) To evaluate whether plasma concentrations of buprenorphine increase proportionally to buprenorphine dose. 2) To evaluate the dose-response of subjective and physiological effects of buprenorphine; and 3) To determine the safety of buprenorphine.
Timeline
- Start
- 1996-11
- Primary completion
- 1998-06
- Completion
- 1998-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Buprenorphine | Other / unclassified | 4 mg | Other |
| Subject | Buprenorphine | Other / unclassified | 8 mg | Other |
| Subject | Buprenorphine | Other / unclassified | 16 mg | Other |
| Subject | Buprenorphine | Other / unclassified | 24 mg | Other |