Comparison of Antiemetic Drugs in Preventing Delayed Nausea After Chemotherapy in Patients With Cancer

NCT00020657 ↗

Phase 3 Completed Gary Morrow National Cancer Institute (NCI) · collab

RandomizedSupportive care

Summary

RATIONALE: Antiemetic drugs may help to reduce or prevent nausea and vomiting in patients being treated with chemotherapy. PURPOSE: This randomized phase III trial is comparing how well different antiemetic drugs work in preventing delayed nausea after chemotherapy in patients who have cancer.

Timeline

Start: 2001-07
Primary completion: 2004-10
Completion: 2004-10

Outcome

Missed primary endpoint

paper groups did not differ in mean severity (p=0.853, one-way ANOVA). PMID 16198982 ↗

Publications

Results Hickok JT, Roscoe JA, Morrow GR, Bole CW, Zhao H, Hoelzer KL, Dakhil SR, Moore T, Fitch TR. 5-Hydroxytryptamine-receptor antagonists versus prochlorperazine for control of delayed nausea caused by doxorubicin: a URCC CCOP randomised controlled trial. Lancet Oncol. 2005 Oct;6(10):765-72. doi: 10.1016/S1470-2045(05)70325-9. Epub 2005 Sep 13.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Granisetron	Other / unclassified	—	Oral
Subject	Ondansetron	Other / unclassified	—	Oral
Subject	Prochlorperazine	Small molecule	10 mg	Oral
Subject	dolasetron	Small molecule	—	Oral