Treatment of Patients With Major Depressive Disorder With MK0869 (0869-063)

Summary

A clinical study to determine the efficacy and safety of MK0869 in the treatment of depression.

Timeline

Start

2002-01-24

Primary completion

2003-12-17

Completion

2003-12-17

Outcome

Missed primary endpoint

paper No statistically significant differences from placebo on the HAM-D(17) were observed at week 8 for either dose of aprepitant in any of the trials PMID 16248986 ↗

Publications

• Results Keller M, Montgomery S, Ball W, Morrison M, Snavely D, Liu G, Hargreaves R, Hietala J, Lines C, Beebe K, Reines S. Lack of efficacy of the substance p (neurokinin1 receptor) antagonist aprepitant in the treatment of major depressive disorder. Biol Psychiatry. 2006 Feb 1;59(3):216-23. doi: 10.1016/j.biopsych.2005.07.013. Epub 2005 Oct 24.

Drugs

Indications