Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event.

Phase 4 Withdrawn MidAmerica Neuroscience Research Foundation at Rowe Neurology Institute Consultants in Neurology · collab

Non-randomizedSingle-groupOpen-labelTreatment

Summary

The participant will receive weekly intramuscular treatment with AVONEX® (interferon beta 1-a) and a one-time high dose intravenous methotrexate with Leucovorin rescue, along with the standard solumedrol treatment before beginning AVONEX® treatment.

Timeline

Start: 2002-05
Primary completion: 2002-12
Completion: 2002-12

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Interferon beta-1a	Protein / enzyme biologic	30 ug	Intramuscular
Subject	Methotrexate	Small molecule	—	Intravenous
Background	Methylprednisolone	Other / unclassified	—	—

Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event.

Summary

Timeline

Drugs

Indications