drugset / Trial / NCT00039455

Trastuzumab and Flavopiridol in Treating Patients With Metastatic Breast Cancer

NCT00039455

Phase 1 Terminated 50 enrolled National Cancer Institute (NCI)
NaSingle-groupOpen-labelTreatment

Summary

Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining trastuzumab with flavopiridol may kill more tumor cells. Phase I trial to study the effectiveness of combining trastuzumab with flavopiridol in treating patients who have metastatic breast cancer

Timeline

Start
2002-04
Primary completion
2004-12
Completion

Drugs

EvaluationDrugModalityDoseRoute
Subject Trastuzumab Monoclonal antibody Intravenous
Subject alvocidib Small molecule Intravenous