Drugs / alvocidib
last change Aug 2021 re-read 9 days ago

alvocidib

Small molecule targets CDK1, CDK2, CDK4, CDK6, CDK7, CDK9 via inhibition

Developed for
cancer of unknown primary site · acute myeloid leukemia · chronic lymphocytic leukemia/small lymphocytic lymphoma · acute myeloblastic leukemia with maturation · acute myeloblastic leukemia without maturation · acute myeloid leukemia with 11q23 abnormalities · acute myeloid leukemia with minimal differentiation · acute myeloid leukemia with t(8;21)(q22;q22) translocation
+81 more · acute myeloid leukemia, t(16;16)(p13.1;q22) · acute myelomonocytic leukemia M4 · adult acute monocytic leukemia · acute erythroid leukemia · acute megakaryoblastic leukemia in adult · adult acute lymphoblastic leukemia · lymphoma · Waldenstrom macroglobulinemia · acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) · acute myeloid leukemia, inv(16)(p13.1;q22) · MALT lymphoma · mantle cell lymphoma · nodal marginal zone B-cell lymphoma · plasma cell myeloma · prolymphocytic leukemia · prostate cancer · splenic marginal zone lymphoma · acute basophilic leukemia · acute myeloid leukemia with multilineage dysplasia · acute myeloid leukemia, del(5q31-q32) · B-cell chronic lymphocytic leukemia · blast phase chronic myelogenous leukemia, BCR-ABL1 positive · breast cancer · cutaneous melanoma · esophageal cancer · pancreatic adenocarcinoma · soft tissue sarcoma · adult nodular lymphocyte predominant Hodgkin lymphoma · adult T-cell leukemia/lymphoma · anaplastic large cell lymphoma · angioimmunoblastic T-cell lymphoma · Burkitt lymphoma · cerebellar astrocytoma · childhood brain stem glioma · childhood ependymoma · childhood kidney neoplasm · childhood medulloblastoma · diffuse gastric adenocarcinoma · diffuse large B-cell lymphoma · endometrial cancer · erythroleukemia · Ewing sarcoma/peripheral primitive neuroectodermal tumor · extragonadal nonseminomatous germ cell tumor · extragonadal seminoma · gastric intestinal type adenocarcinoma · gastroesophageal junction adenocarcinoma · gastrointestinal stromal tumor · grade III lymphomatoid granulomatosis · head and neck cancer · hematopoietic and lymphoid system neoplasm · HER2 positive breast carcinoma · Hodgkin's lymphoma, lymphocytic depletion · Hodgkin's lymphoma, mixed cellularity · Hodgkins lymphoma · leukemia · liver and intrahepatic bile duct neoplasm · liver cancer · male breast carcinoma · malignant childhood germ cell neoplasm · malignant epithelial tumor of ovary · malignant pleural mesothelioma · malignant testicular germ cell tumor · mycosis fungoides and variants · myelodysplastic syndrome · myelodysplastic syndrome with excess blasts · neuroblastoma · nodular sclerosis classical Hodgkin lymphoma · non-small cell lung carcinoma · optic pathway glioma · osteosarcoma · ovarian germ cell tumor · precursor lymphoblastic lymphoma/leukemia · primary peritoneal carcinoma · refractory hairy cell leukemia · refractory plasma cell neoplasm · renal cell carcinoma · retinoblastoma · rhabdomyosarcoma · small cell carcinoma · small intestine cancer · supratentorial primitive neuroectodermal tumor
Investigated by
National Cancer Institute (NCI) · Memorial Sloan Kettering Cancer Center · Sumitomo Pharma America, Inc. · NCIC Clinical Trials Group · AbbVie · Barbara Ann Karmanos Cancer Institute
+7 more · Gynecologic Oncology Group · M.D. Anderson Cancer Center · Mayo Clinic · SWOG Cancer Research Network · Sanofi · Sumitomo Pharma Co., Ltd. · Virginia Commonwealth University

Trials 64 · started per year

today
3
2
1
7
7
6
5
8
2
7
2
3
2
1
1
1
1
3
2
1997199819992000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 133 trials
Phase 1 NCT03441555 May 2018 → Jan 2021 acute myeloid leukemia AbbVie Completed No outcome recorded
Phase 1 NCT03563560 May 2018 → Mar 2020 acute myeloid leukemia Sumitomo Pharma Co., Ltd. Completed No outcome recorded
Phase 1 NCT03298984 Sep 2017 → Mar 2020 acute myeloid leukemia Sumitomo Pharma America, Inc. Completed No outcome recorded
Phase 1 NCT01076556 Apr → Jul 2010 chronic lymphocytic leukemia/small lymphocytic lymphoma, prolymphocytic leukemia National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT00735930 Aug 2008 → Mar 2013 anemia, chronic lymphocytic leukemia/small lymphocytic lymphoma, prolymphocytic leukemia, thrombocytopenia National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT00470197 Apr 2007 → Jan 2011 acute erythroid leukemia, acute megakaryoblastic leukemia in adult, acute myeloblastic leukemia with maturation, acute myeloblastic leukemia without maturation +8 National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT00377104 Sep 2006 → Nov 2012 chronic lymphocytic leukemia/small lymphocytic lymphoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT00324480 Mar 2006 → Apr 2009 cancer of unknown primary site National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT00112684 Feb 2006 → Jul 2012 cancer of unknown primary site National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1 NCT00278330 Jan 2006 → Oct 2009 acute myeloid leukemia, adult acute lymphoblastic leukemia, blast phase chronic myelogenous leukemia, BCR-ABL1 positive, myelodysplastic syndrome with excess blasts National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/27 trials
Phase 1/2 NCT04493099 Oct 2020 acute myeloid leukemia M.D. Anderson Cancer Center Withdrawn No outcome recorded Stop: Business
Phase 1/2 NCT03593915 Aug 2018 → Aug 2021 myelodysplastic syndrome Sumitomo Pharma America, Inc. Terminated No outcome recorded Stop: Business
Phase 1/2 NCT00445341 Nov 2006 → Apr 2012 lymphoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/2 NCT00112723 Dec 2005 → Feb 2011 Hodgkin's lymphoma, lymphocytic depletion, Hodgkin's lymphoma, mixed cellularity, MALT lymphoma, Waldenstrom macroglobulinemia +12 National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1/2 NCT00058240 Apr 2003 → Feb 2009 Waldenstrom macroglobulinemia, chronic lymphocytic leukemia/small lymphocytic lymphoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/2 NCT00016016 Feb 2001 → Nov 2006 acute myeloid leukemia, adult acute lymphoblastic leukemia National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/2 NCT00020332 Oct 2000 → Mar 2003 breast cancer National Cancer Institute (NCI) Completed No outcome recorded
Phase 224 trials · 1 met primary · 1 missed
Phase 2 NCT03969420 Jan 2020 → Apr 2021 acute myeloid leukemia Sumitomo Pharma America, Inc. Terminated No outcome recorded Stop: Business
Phase 2 NCT02520011 Mar 2016 → Feb 2020 acute myeloid leukemia Sumitomo Pharma America, Inc. Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT01349972 Apr 2011 → May 2014 acute erythroid leukemia, acute myeloblastic leukemia with maturation, acute myeloblastic leukemia without maturation, acute myeloid leukemia with 11q23 abnormalities +8 National Cancer Institute (NCI) Completed Met primary
Phase 2 NCT00991952 Sep 2009 → Feb 2012 diffuse gastric adenocarcinoma, gastric intestinal type adenocarcinoma, gastroesophageal junction adenocarcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00957905 Jun 2009 → Aug 2014 extragonadal nonseminomatous germ cell tumor, extragonadal seminoma, malignant testicular germ cell tumor, ovarian germ cell tumor National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00795002 Nov 2008 → Nov 2010 acute erythroid leukemia, acute megakaryoblastic leukemia in adult, acute myeloblastic leukemia with maturation, acute myeloblastic leukemia without maturation +9 National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00634244 Oct 2008 → Sep 2014 acute erythroid leukemia, acute megakaryoblastic leukemia in adult, acute myeloblastic leukemia with maturation, acute myeloblastic leukemia without maturation +7 National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00464633 Mar 2007 → Dec 2011 chronic lymphocytic leukemia/small lymphocytic lymphoma Sanofi Completed No outcome recorded
Phase 2 NCT00407966 Oct 2006 → Jul 2008 acute basophilic leukemia, acute erythroid leukemia, acute megakaryoblastic leukemia in adult, acute myeloblastic leukemia with maturation +8 National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00331682 Mar 2006 → May 2008 pancreatic adenocarcinoma National Cancer Institute (NCI) Completed No outcome recorded

Evidence & citations 20 cited values

Every value below carries the sentence it was read from. 67 sources stand behind the page.

FieldValueCited text
Known as alvocidib “Flavopiridol (alvocidib)” NCT00094978 ↗
61

NCT00377104 ↗

NCT00005971 ↗

NCT00047203 ↗

NCT00991952 ↗

NCT00324480 ↗

NCT00331682 ↗

NCT00006245 ↗

NCT00005074 ↗

NCT00735930 ↗

NCT00016185 ↗

Show 51 more sources

Known as Alvocidib freebase ChEMBL registry synonym — accepted as the source's own label CHEMBL428690 ↗
Known as Alvocidib Hydrochloride ClinicalTrials.gov intervention name — accepted as the source's own label NCT04493099 ↗
Known as FLAVO “To determine a safe and tolerated dose of flavopiridol (alvocidib) in combination with standard dose rituximab and fludarabine” NCT00058227 ↗
Known as flavopiridol “A Non-randomized Phase 2 Study of Alvocidib (Flavopiridol) Plus Oxaliplatin with or without 5-FU and Leucovorin for Relapsed or Refractory Germ-Cell Tumors” NCT00957905 ↗
6

“Phase I Trial of Bortezomib (PS-341; NSC 681239) and Alvocidib (Flavopiridol NSC 649890) in Patients with Recurrent or Refractory Indolent B-Cell Neoplasms” NCT00082784 ↗

“Drugs used in chemotherapy, such as irinotecan and flavopiridol, work in different ways to stop tumor cells from dividing so they stop growing or die.” NCT00087282 ↗

“To determine a safe and tolerated dose of flavopiridol (alvocidib) in combination with standard dose rituximab and fludarabine” NCT00058227 ↗

“Alvocidib (flavopiridol), administered intravenously, + cytarabine (Ara-C), administered by subcutaneous injection” NCT03969420 ↗

NCT00445341 ↗

NCT00094978 ↗

Known as Flavopiridol hydrochloride ChEMBL registry synonym — accepted as the source's own label CHEMBL428690 ↗
Known as HL 275 ChEMBL registry synonym — accepted as the source's own label CHEMBL428690 ↗
Known as HMR 1275 ChEMBL registry synonym — accepted as the source's own label CHEMBL428690 ↗
Known as L 86 8275 ChEMBL registry synonym — accepted as the source's own label CHEMBL428690 ↗
Known as MDL 107,826A ChEMBL registry synonym — accepted as the source's own label CHEMBL428690 ↗
Known as NSC 649890 “Phase I Trial of Bortezomib (PS-341; NSC 681239) and Alvocidib (Flavopiridol NSC 649890) in Patients with Recurrent or Refractory Indolent B-Cell Neoplasms” NCT00082784 ↗
Action Inhibit “the cyclin dependent kinase (cdk) inhibitor flavopiridol” PMID 15122079 ↗ Aug 2004
5

“Cyclin-dependent kinase 7 inhibitor” CHEMBL428690 ↗

“Cyclin-dependent kinase 6 inhibitor” CHEMBL428690 ↗

“Cyclin-dependent kinase 4 inhibitor” CHEMBL428690 ↗

“Cyclin-dependent kinase 1 inhibitor” CHEMBL428690 ↗

“Cyclin-dependent kinase 2 inhibitor” CHEMBL428690 ↗

Modality Small molecule “Flavopiridol is a synthetic N-methylpiperidinyl, chlorophenyl flavone compound” NCT00445341 ↗
1

CHEMBL428690 ↗

Route Intravenous “Given IV” NCT00003620 ↗
Target CDK1 “Cyclin-dependent kinase 1 inhibitor” CHEMBL428690 ↗
Target CDK2 “Cyclin-dependent kinase 2 inhibitor” CHEMBL428690 ↗
Target CDK4 “Cyclin-dependent kinase 4 inhibitor” CHEMBL428690 ↗
Target CDK6 “Cyclin-dependent kinase 6 inhibitor” CHEMBL428690 ↗
Target CDK7 “Cyclin-dependent kinase 7 inhibitor” CHEMBL428690 ↗
Target CDK9 “Alvocidib is a cyclin-dependent kinase 9 inhibitor leading to downregulation of the antiapoptotic BCL-2 family member, MCL-1.” PMID 32998965 ↗ Sep 2020