drugset / Trial / NCT00053872

Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma

NCT00053872

Phase 3 Unknown 316 enrolled University of Leicester
RandomizedTreatment

Summary

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving radiation therapy in different ways with combination chemotherapy may kill any remaining tumor cells following surgery. It is not yet known which radiation therapy regimen combined with combination chemotherapy is more effective in treating medulloblastoma. PURPOSE: Randomized phase III trial to compare different radiation therapy regimens plus combination chemotherapy in treating children who have undergone surgery for medulloblastoma.

Timeline

Start
2003-02
Primary completion
Completion

Drugs

EvaluationDrugModalityDoseRoute
Subject Cisplatin Other / unclassified Intravenous
Subject Lomustine Small molecule Oral
Subject Vincristine Small molecule Intravenous