Vincristine
Regulatory milestones approvals, filings & regulatory actions · 3 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansions (2) | US (FDA) | ONCOVIN | — | 1982-12-09 – 2007-12-07 | fda.gov ↗ |
| Approved | US (FDA) | ONCOVIN | — | 1963-07-10 | fda.gov ↗ |
Trials 585 · started per year
Press releases naming this drug 6 releases
| Date | Issuer | Release |
|---|---|---|
| 2019-03-07 | CASI pharmaceuticals, Inc. | CASI Pharmaceuticals Announces China National Medical Products Administration (NMPA) Approval Of CTA To Conduct Registration Trial For MARQIBO® issuerdirect.com ↗ |
| 2016-01-12 | CASI pharmaceuticals, Inc. | CASI Pharmaceuticals' Import Drug Registration Application For MARQIBO® Accepted For Review By CFDA issuerdirect.com ↗ |
| 2000-04-05 | Teva Branded Pharmaceutical Products R&D, Inc. | Teva Announces Completion of Novopharm Acquisition tevapharm.com ↗ |
| 2000-02-01 | Teva Branded Pharmaceutical Products R&D, Inc. | Teva Pharmaceutical Industries Ltd. Signs Definitive Agreement to Acquire Novopharm Ltd. tevapharm.com ↗ |
| 1999-12-02 | Teva Branded Pharmaceutical Products R&D, Inc. | Teva Pharmaceutical Industries Ltd. signs letter of intent to acquire Novopharm Limited tevapharm.com ↗ |
| 1999-10-19 | Teva Branded Pharmaceutical Products R&D, Inc. | Teva Pharmaceutical confirms discussions to acquire Novopharm Ltd. tevapharm.com ↗ |
Evidence & citations 47 cited values
Every value below carries the sentence it was read from. 1,287 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | vincristine | “Standard Induction chemotherapy care included: vincristine, doxorubicin, and dexamethasone (VAD) (0.5 mg, 10 mg/m2, and 40 mg, respectively);dexamethasone,...” NCT00577096 ↗1128“Control chemotherapy treatment will be chosen from any of the following standard-of-care chemotherapy drugs or combinations: * Carboplatin; * Irinotecan; * Etoposide; *...” NCT03632135 ↗ “Patients initially received one 21-day cycle of standard rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP; rituximab 375 mg/m2, cyclophosphamide...” PMID 30948276 ↗ Apr 2019 “One or more of the following may be assigned by the physician (physician's choice) per standard of care guidelines upon study enrollment following surgery: Cytarabine,...” NCT06861244 ↗ “Consolidation 6-thioguanine 60 mg/m2/d, 1 to 43 po; prednisone 40 mg/m2/d, on days 1-28 orally; vincristine 1.5 mg/m2/d, days 1, 8, 15, 22; idarubicin 7 mg/m2/d, on days 1, 8,...” NCT06211452 ↗ “A Phase 3 Open Label Multicenter, Randomized Study to Compare the Efficacy and Safety of the Zevalin (Ibritumomab Tiuxetan) Therapeutic Regimen Following Cyclophosphamide,...” NCT00384111 ↗ “The patients will be given RCHOP (Rituximab 375mg/m2 ivgtt, D0, Cyclophosphamide 750mg/m2, ivgtt D1, doxorubicin 50mg/m2,ivgtt D1, Vincristine 1.4mg/m2（max 2mg）, ivgtt D1...” NCT04842318 ↗ “standard CHOP chemotherapy (cyclophosphamide, 750mg per square meter of body-surface area,d1, vincristine, 1.4mg per square meter of body-surface area, maximal dose is 2mg d1,...” NCT02487316 ↗ “This study evaluates the addition of Acalabrutinib to current standard therapy of Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone (R-CHOP) for patients...” NCT04546620 ↗ “The R-CHOP treatment will continue up to 3 cycles with interval of 21 days: Each cycle consists of rituximab 375mg/m2 (iv, on day 1), cyclophosphamide 750 mg/m2 (iv, on day 1),...” NCT01279902 ↗ “The purpose of the study is to assess the efficacy of the association of Lenalidomide (Revlimid) and R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, vincristine and...” NCT01393756 ↗ |
| Known as | 22-oxovincaleukoblastine | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | 37231 | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | Cellcristin | “Vincristine (Cellcristin®)” NCT02085148 ↗ |
| Known as | Kyocristine | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | Leucristine | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | leurocristine | “Vincristine, also known as leurocristine and marketed under the brand name Oncovin among others, is a chemotherapy medication used to treat various types of cancer such as...” NCT04747912 ↗ |
| Known as | Leurocristine sulfate | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | LILLY-37231 | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | Liposomal Vincristine | “Phase I-II Study of Liposomal Vincristine (VSLI) and Dexamethasone in Relapsed or Refractory Acute Lymphoblastic Leukemia” NCT00144963 ↗ |
| Known as | Marqibo | “This is a pilot study utilizing Marqibo® (vincristine sulfate liposome injection) combined with dexamethasone, mitoxantrone and asparaginase (UK ALL R3) for relapsed acute...” NCT02879643 ↗5“Marqibo, a sphingosomal/cholesterol encapsulation of vincristine sulfate has targeted, increased, and sustained delivery of vincristine to tumor tissues.” PMID 19536896 ↗ Aug 2009 “Marqibo® (vincristine sulfate liposomes injection)” NCT00495079 ↗ “Vincristine Sulfate Liposomal Injection (Marqibo)” NCT04448834 ↗ “Marqibo” NCT00567567 ↗ |
| Known as | Marqibo kit | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | Novopharm | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | NSC-67574 | “5-Fluorouracil, 5-FU, NSC-19893; Methyl-CCNU, MeCCNU, NSC-95441; Vincristine, VCR, NSC-67574.” NCT00427570 ↗9“Vincristine, VCR, NSC-67574” NCT00002499 ↗ “Vincristine, VCR, NSC-67574” NCT00002476 ↗ “Vincristine, VCR, NSC-67574” NCT00002471 ↗ “Vincristine, VCR, NSC-67574” NCT00002462 ↗ “VCR Vincristine, NSC-67574” NCT00002599 ↗ “VCR Vincristine, NSC-67574” NCT00001339 ↗ “VCR Vincristine, NSC-67574” NCT00002576 ↗ “VCR Vincristine, NSC-67574” NCT00002691 ↗ “VCR Vincristine, NSC-67574” NCT00002565 ↗ |
| Known as | Oncotcs | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | oncovin | “The drugs in this combination are "R" for rituximab, "C" for cyclophosphamide, "H" for doxorubicin which has a chemical name of hydroxydaunomycin, "O" for vincristine which has...” NCT02285062 ↗15“Maintenance therapy with dose-reduced POMP (purinethol [6-mercaptopurine], oncovin [vincristine sulfate], methotrexate, and prednisone) was given for 3 years.” PMID 29352703 ↗ Jan 2018 “CHOP (cyclophosphamide, hydroxydaunorubicin [doxorubicin], Oncovin [vincristine], prednisone)” NCT06947967 ↗ “CHOP (cyclophosphamide, hydroxydaunorubicin [doxorubicin], Oncovin [vincristine], prednisone)” NCT06006117 ↗ “CHOP (cyclophosphamide, hydroxydaunorubicin [doxorubicin], Oncovin [vincristine], prednisone)” NCT00719472 ↗ “Cyclophosphamide, Hydroxydaunorubicin (doxorubicin), Oncovin (vincristine), and Prednisone” NCT06072131 ↗ “cyclophosphamide, Oncovin [vincristine], prednisone (COP) reduction therapy” PMID 17138821 ↗ Apr 2007 “CHOP: Cyclophosphamide, Hydroxydaunorubicin, Oncovin, Prednisone” NCT00974324 ↗ “vincristine (Oncovin), cyclophosphamide” PMID 28601705 ↗ Jun 2017 “Vincristine (oncovin)®” PMID 33394214 ↗ Jan 2021 |
| Known as | Oncovin(R) Vincristine | “Oncovin(R) (vincristine)” NCT00602667 ↗1“Oncovin(R) Vincristine” NCT00991211 ↗ |
| Known as | Tecnocris | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | VCR | “Vincristine sulfate liposome injection (VSLI,) is a sphingomyelin and cholesterol nanoparticle formulation of vincristine sulfate (VCR) that was designed to overcome the dosing...” PMID 23907766 ↗ Aug 201336“Marqibo (vincristine sulfate liposome injection, VSLI) is a novel liposomal formulation of vincristine sulfate (VCR) being developed for the systemic treatment of cancer.” PMID 20978276 ↗ Oct 2010 “Vincristine sulfate (VCR) is an inhibitor of microtubule formation in the mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage.” NCT04402073 ↗ “Participants will be uniformly treated with four drug-induction: vincristine (VCR), prednisone (PDN), pegylated asparaginase (PegASP), daunorubicin (DNR).” NCT07443592 ↗ “Patients will be uniformly treated with four drug-induction: vincristine (VCR), prednisone (PDN), pegylated asparaginase (PegASP), daunorubicin (DNR).” NCT04179929 ↗ “During radiation, patients received 15 to 30 doses of carboplatin (30-45 mg/m(2)/dose), along with vincristine (VCR) once per week for 6 weeks.” PMID 22665539 ↗ Jun 2012 “Vincristine (VCR): 1.5 mg/m2 (max 2 mg) IV d 1, 8, 15, 22 in induction VCR 2 mg, IV, d 1,8 in consolidation (cycle 1, 2)” NCT00853008 ↗ “5-Fluorouracil, 5-FU, NSC-19893; Methyl-CCNU, MeCCNU, NSC-95441; Vincristine, VCR, NSC-67574.” NCT00427570 ↗ “treated with carboplatin (CBDCA) and vincristine (VCR) every 3 weeks for 24 weeks” NCT00002794 ↗ “vincristine (VCR) and daunorubicin hydrochloride (DNR) once weekly in weeks 2-5” NCT00430118 ↗ “Dex 6 mg/m2 PO; in 3 divided doses daily x 7 VCR 1.5 mg/m2 IV (max. 2.0 mg)” NCT00187057 ↗ |
| Known as | VDS | “Cyclophosphamide (Cy) + Doxorubicin (ADM) + Vincristine (VDS) + Prednisone (Pred) ]± Rituximab (R)” NCT06520163 ↗ |
| Known as | Vincaleukoblastine, 22-oxo- | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | Vincasar pfs | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | Vincrex | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | vincristin | “Vincristin 1.4 mg/ms (maximum 2.0 mg total dose) iv day+1” NCT02223208 ↗12“VINCRISTIN: Dosage 1.4 mg/m2 (max. 2.0 mg/m2, IV, day 1” NCT01361191 ↗ “Vincristin 1.4mg/m2 day +1” NCT01679860 ↗ |
| Known as | Vincristin: L01CA02 | “Vincristin: L01CA02” NCT01614132 ↗ |
| Known as | Vincristina | “Rituximab: 375 mg/mq day 1 Ciclofosfamide: 750 mg/mq day 1, Vincristina: 1,4 mg/mq day 1 Prednisone: 40 mg/mq day 1-5,” NCT00774826 ↗ |
| Known as | Vincristine (Oncovin) | “Vincristine (Oncovin)” NCT00659269 ↗1“Vincristine (Oncovin)” NCT01527422 ↗ |
| Known as | Vincristine (V) | “Vincristine (V)” NCT01858922 ↗ |
| Known as | Vincristine PFS | “One or more of the following may be assigned by the physician (physician's choice) per standard of care guidelines upon study enrollment following surgery: Cytarabine,...” NCT06861244 ↗ |
| Known as | vincristine sulfate | “Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells” NCT00896519 ↗194“Maintenance therapy with dose-reduced POMP (purinethol [6-mercaptopurine], oncovin [vincristine sulfate], methotrexate, and prednisone) was given for 3 years.” PMID 29352703 ↗ Jan 2018 “Vincristine sulfate (VCR) is an inhibitor of microtubule formation in the mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage.” NCT04402073 ↗ “Vincristine sulfate was administered at a dose of 2 mg (fixed dose)” NCT01435018 ↗ “vincristine sulfate (VCR) IV weekly on weeks 1-10, 12, 15, and 18” NCT00002611 ↗ “Vincristine sulfate 1.5 mg/m2 IV will be given weekly x 6.” NCT00003203 ↗ “Vincristine Sulfate Liposomal Injection (Marqibo)” NCT04448834 ↗ “* Vincristine sulfate (1.4 mg/m2) (2 mg maximum)” NCT02605694 ↗ “vincristine sulfate IV on days 1, 8, 15, and 22” NCT00061945 ↗ “vincristine sulfate IV on days 5 and 12” NCT01412879 ↗ “vincristine (vincristine sulfate)” NCT00945009 ↗ |
| Known as | Vincristine Sulfate For Injection | “Vincristine Sulfate For Injection 1.4mg/m2,(2mg, maximum dose), iv, d1, d8, d15, d22.” NCT02072785 ↗ |
| Known as | Vincristine sulfate liposomal | “Marqibo® (Vincristine sulfate liposomal) will be administered intravenously over 60 minutes (±10 minutes) every 7 days (±3 days) (Days 1, 8, 15, 22) for four doses (1 cycle).” NCT01222780 ↗ |
| Known as | vincristine sulfate liposomal injection | “Vincristine sulfate liposomal injection is FDA approved for the treatment of patients with recurrent Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).” PMID 35641232 ↗ Jul 2022 |
| Known as | Vincristine Sulfate Liposome | “Drug: Vincristine Sulfate Liposome” NCT00025259 ↗ |
| Known as | Vincristine Sulfate Liposome For Injection | “Vincristine Sulfate Liposome For Injection: 1.4mg/m2, (2mg, maximum dose), iv, d1, d8, d15, d22.” NCT02072785 ↗ |
| Known as | Vincristine Sulfate Liposome Injection | “This is a pilot study utilizing Marqibo® (vincristine sulfate liposome injection) combined with dexamethasone, mitoxantrone and asparaginase (UK ALL R3) for relapsed acute...” NCT02879643 ↗ |
| Known as | Vincristine Sulfate Liposomes Injection | “Phase I Trial to Evaluate the Safety, Activity and Pharmacokinetics of Marqibo(Registered Trademark) (Vincristine Sulfate Liposomes Injection) in Children and Adolescents With...” NCT01222780 ↗1“Drug: Vincristine Sulfate Liposomes Injection” NCT00144963 ↗ |
| Known as | Vincristine sulfate pfs | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | Vincristine sulphate | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | Vincristini sulfas | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | Vincrisul | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | Vinkristin | ChEMBL registry synonym — accepted as the source's own label CHEMBL90555 ↗ |
| Known as | VSLI | “Vincristine sulfate liposome injection (VSLI), a liposomal formulation of vincristine, may be better tolerated than standard aqueous vincristine and enable dose intensification.” PMID 39937083 ↗ Feb 20252“Phase I-II Study of Liposomal Vincristine (VSLI) and Dexamethasone in Relapsed or Refractory Acute Lymphoblastic Leukemia” NCT00144963 ↗ “VSLI (Vincristine Sulfate Liposome Injection, 0.16 mg/mL)” NCT00145041 ↗ |
| Known as | VSLI-RTU | “Marqibo formulation and the 1-vial VSLI-RTU formulation of vincristine are administered in a 2-way crossover design over 2 treatment cycles (21 days each):” NCT04243434 ↗ |
| Action | Inhibit | “Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells” NCT00972478 ↗ |
| Modality | Small molecule | “vinca alkaloid” NCT01463852 ↗ |
| Route | Intravenous | “Four medicines are given on day 1 of each cycle by vein (IV) (doxorubicin, cyclophosphamide, bleomycin, vincristine).” NCT00000689 ↗ |