drugset / Trial / NCT05844670
CHildren Treated With Vincristine: A Trial Regarding Pharmacokinetics, DNA And Toxicity of Targeted Therapy In Pediatric Oncology Patients.
Phase 4
Unknown
100 enrolled
Moi University
Amsterdam UMC, location VUmc · collabPrincess Maxima Center for Pediatric Oncology · collab
NaSingle-groupOpen-labelTreatment
Summary
The goal of this clinical trial is to individualize the dosage of vincristine, a chemotherapy drug, in children with cancer. The main question it aims to answer is: can vincristine dosage be optimized while carefully monitoring toxicity. The following will happen: * Participants will receive vincristine according to the institutional treatment protocol. * After receiving vincristine, blood samples will be taken at three time points. * The amount of vincristine in the blood samples will be determined. * If the amount of vincristine in the blood samples is lower than the reference and the participants do not experience toxicity due to vincristine, the dose of vincristine may be increased. * Toxicity will be carefully monitored.
Timeline
- Start
- 2023-04-20
- Primary completion
- 2024-08-01
- Completion
- 2024-11-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Vincristine | Small molecule | — | — |