drugset / Trial / NCT00005796
Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors
NaSingle-groupOpen-labelTreatment
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Inserting a specific gene into a person's peripheral stem cells may improve the body's ability to fight cancer or make the cancer more sensitive to chemotherapy. PURPOSE: Phase I trial to study the effectiveness of combination chemotherapy plus gene therapy in treating patients who have CNS tumors.
Timeline
- Start
- 2000-02
- Primary completion
- 2003-06
- Completion
- 2011-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lomustine | Small molecule | — | Oral |
| Subject | Vincristine | Small molecule | — | Intravenous |
| Subject | fibronectin assisted retroviral vector expressing human O6-methylguanine DNA methyltransferase | Unknown | — | — |
| Subject | procarbazine | Small molecule | — | Oral |