drugset / Trial / NCT00199069
German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93)
RandomizedParallel-groupOpen-labelTreatment
Summary
The study evaluates the efficacy and tolerability of a risk- and subtype-adapted chemotherapy over one year, followed by randomized either intensified or conventional maintenance therapy. It includes a distinct protocol for the subgroup 'mature B-ALL',
Timeline
- Start
- 1993-04
- Primary completion
- 1999-01
- Completion
- 2001-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | 6-thioguanine | Other / unclassified | — | — |
| Subject | Cyclophosphamide | Other / unclassified | — | — |
| Subject | Cytarabine | Small molecule | — | — |
| Subject | Daunorubicin | Small molecule | — | — |
| Subject | Dexamethasone | Small molecule | — | — |
| Subject | Ifosfamide | Small molecule | — | — |
| Subject | MERCAPTOPURINE ANHYDROUS | Small molecule | — | — |
| Subject | Methotrexate | Small molecule | — | — |
| Subject | Mitoxantrone | Small molecule | — | — |
| Subject | Prednisolone | Other / unclassified | — | — |
| Subject | Teniposide | Small molecule | — | — |
| Subject | Vincristine | Small molecule | — | — |
| Subject | asparaginase | Protein / enzyme biologic | — | — |