Drugs / 6-thioguanine
Trials 7
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/22 trials | ||||||
| Phase 1/2 | NCT05276284 | Sep 2022 → Dec 2024 | metastatic malignant neoplasm | Kristoffer Rohrberg | Completed | No outcome recorded |
| Phase 1/2 | NCT02141100 | Jul 2014 → Oct 2016 | non-Hodgkin lymphoma | Kjeld Schmiegelow | Withdrawn | No outcome recorded |
| Phase 23 trials | ||||||
| Phase 2 | NCT00176462 | Feb 2001 → Sep 2008 | acute lymphoblastic leukemia | Rutgers, The State University of New Jersey | Completed | No outcome recorded |
| Phase 2 | NCT00588536 | Jan 1995 → Jul 2008 | Langerhans cell histiocytosis | Memorial Sloan Kettering Cancer Center | Completed | No outcome recorded |
| Phase 2 | NCT00587873 | Mar 1994 → Dec 2003 | Hodgkins lymphoma | Memorial Sloan Kettering Cancer Center | Completed | No outcome recorded |
| Phase 31 trial · 1 missed | ||||||
| Phase 3 | NCT06211452 | Aug 2007 → Mar 2015 | childhood acute myeloid leukemia | Grupo Argentino de Tratamiento de la Leucemia Aguda | Completed | Missed primary |
| Phase 41 trial | ||||||
| Phase 4 | NCT00199069 | Apr 1993 → Jan 1999 | adult acute lymphoblastic leukemia | Goethe University | Completed | No outcome recorded |
| Comparator or background therapy4 trials | ||||||
| Phase 1/2 | NCT00439296 Background | May 2006 → May 2009 | childhood acute lymphoblastic leukemia | Therapeutic Advances in Childhood Leukemia Consortium | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT00184041 Background | Jul 2004 → Dec 2011 | adult acute lymphoblastic leukemia | University of Southern California | Completed | No outcome recorded |
| Phase 2 | NCT00504660 Comparator | Sep 2003 → Aug 2010 | brain cancer, glioblastoma | M.D. Anderson Cancer Center | Completed | No outcome recorded |
| Phase 3 | NCT00925873 Comparator | Jun 1996 → Apr 2000 | acute myeloid leukemia | French Innovative Leukemia Organisation | Completed | No outcome recorded |
Evidence & citations 4 cited values
Every value below carries the sentence it was read from. 11 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | 6-Thioguanine | “Consolidation 6-thioguanine 60 mg/m2/d, 1 to 43 po; prednisone 40 mg/m2/d, on days 1-28 orally; vincristine 1.5 mg/m2/d, days 1, 8, 15, 22; idarubicin 7 mg/m2/d, on days 1, 8,...” NCT06211452 ↗10“Maintenance therapy for one year with 6-thioguanine (100 mg/m2/d orally on days 1 through 4 every week)” NCT00925873 ↗ |
| Known as | 6TG | “2. 6-thioguanine (6TG) 12.5 mg/m2 orally taken once a day,” NCT05276284 ↗ |
| Modality | Other / unclassified | “The thiopurines 6-mercaptopurine (6MP) and 6-thioguanine (6TG) are prodrugs” NCT05276284 ↗ |
| Route | Oral | “60 mg/m2/day to be given orally on days 1 through 14.” NCT00439296 ↗ |