drugset / Trial / NCT00588536
Study of Sequential Administration of Oral 6-Thioguanine After Methotrexate in Patients With LCH
NaSingle-groupOpen-labelTreatment
Summary
The objective of this study is to determine the incidence of complete and partial response and the duration of response in patients with Langerhans Cell Histiocytosis (LCH) treated with sequential administration of oral 6-Thioguanine (6-TG) after Methotrexate (MTX).
Timeline
- Start
- 1995-01
- Primary completion
- 2008-07
- Completion
- 2009-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Methotrexate | Small molecule | 1 mg/kg | Oral |
| Subject | Methotrexate | Small molecule | 30 mg/m2 | Oral |
| Subject | Thioguanine | Small molecule | 10 mg/kg | Oral |
| Subject | Thioguanine | Small molecule | 300 mg/m2 | Oral |
| Background | Leucovorin | Small molecule | 5 mg | Oral |