drugset / Trial / NCT02141100
Study of 6-Thioguanine in Combination With 6-Mercaptopurine During Maintenance Therapy of Childhood Lymphoma
Phase 1/2
Withdrawn
Kjeld Schmiegelow
Aalborg University Hospital · collabAarhus University Hospital Skejby · collabOdense University Hospital · collab
NaSingle-groupOpen-labelTreatment
Summary
The purpose of this phase 1-2 study is to explore the applicability of supplementing standard methotrexate/6-mercaptopurine (MTX/6MP) maintenance therapy of children with non-Hodgkin lymphoma with 6-thioguanine (6TG). The investigators hypothesize that addition of 6TG to 6MP-based maintenance therapy of patients with high TPMT activity will mimic the more favourable thiopurine metabolism of patients with low TPMT activity and ultimately reduce relapse rates.
Timeline
- Start
- 2014-07
- Primary completion
- 2016-10
- Completion
- 2016-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Thioguanine | Small molecule | 12.5 mg/m2 | — |