drugset / Trial / NCT00587873
Sequential Administration of Oral 6-Thioguanine (6-TG) After Methotrexate (MTX) in Patients With Relapsed Hodgkin's Disease (Phase II)
NaSingle-groupOpen-labelTreatment
Summary
The objective of this study is to determine the incidence of complete and partial response and the duration of response in patients with recurrent or resistant Hodgkin's disease (HD) treated with sequential administration of oral 6-Thioguanin (6-TG) after IV Methotrexate (MTX).
Timeline
- Start
- 1994-03
- Primary completion
- 2003-12
- Completion
- 2009-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Methotrexate | Small molecule | 24 mg/m2 | Intravenous |
| Subject | Thioguanine | Small molecule | 300 mg/m2 | Oral |
| Background | Leucovorin | Small molecule | 5 mg | Oral |