Botanical/Drug Interactions in HIV: Glucuronidation

Phase 1 Completed 60 enrolled National Center for Complementary and Integrative Health (NCCIH)

RandomizedParallel-groupOpen-labelPrevention

Summary

A series of clinical studies will be conducted in normal, healthy adult volunteers to evaluate the potential for alterations in the pharmacokinetics of anti HIV drugs when botanicals/nutriceuticals are given concurrently via the oral route. Both the drugs and botanicals are known to rely upon or to modulate, respectively, metabolism via glucuronidation.

Timeline

Start: 2003-09
Primary completion: —
Completion: 2006-03

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Silymarin	Traditional medicine (herbal / TCM)	—	Oral

Indications

No indication recorded.