Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment

Phase 2 Completed 70 enrolled University of South Florida National Cancer Institute (NCI) · collab

Non-randomizedCrossoverOpen-labelSupportive care

Summary

RATIONALE: Cyproheptadine and megestrol may improve appetite and help prevent weight loss in children with cancer. PURPOSE: This phase II trial is studying how well cyproheptadine and megestrol work in improving appetite and preventing weight loss in children with cachexia caused by cancer or cancer treatment.

Timeline

Start: 2003-06
Primary completion: 2007-08
Completion: 2007-08

Publications

Results Couluris M, Mayer JL, Freyer DR, Sandler E, Xu P, Krischer JP. The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. J Pediatr Hematol Oncol. 2008 Nov;30(11):791-7. doi: 10.1097/MPH.0b013e3181864a5e.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cyproheptadine	Small molecule	0.25 mg/kg	Oral
Subject	Megestrol Acetate	Other / unclassified	10 unknown	Oral

Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment

Summary

Timeline

Publications

Drugs

Indications