drugset / Trial / NCT00070629

CPG 7909 Injection in Non-Small Cell Lung Cancer

NCT00070629

Phase 2 Completed 116 enrolled Pfizer
RandomizedParallel-groupOpen-labelTreatment

Summary

Eligible patients will be randomized in a ratio of 2:1 to receive either chemotherapy (a taxane and a platinum compound) plus CPG 7909 Injection or chemotherapy alone. Protocol therapy will be administered until disease progression or intolerable toxicity. CpG 7909 Injection will be administered subcutaneously, on Weeks 2 and 3 of each three-week cycle (days 8 and 15) and chemotherapy will be administered on Week 1 (Day 1). Patients will undergo complete disease evaluation at the end of every other treatment cycle until disease progression.

Timeline

Start
2003-05
Primary completion
Completion
2007-07

Drugs

EvaluationDrugModalityDoseRoute
Subject agatolimod Oligonucleotide (other) 0.2 mg/kg Subcutaneous
Background Carboplatin Small molecule 6 unknown
Background Cisplatin Other / unclassified 75 mg/m2
Background Docetaxel Small molecule 75 mg/m2
Background Paclitaxel Small molecule 175 mg/m2