Lonafarnib and Temozolomide in Treating Patients With Recurrent Primary Supratentorial Gliomas

Summary

RATIONALE: Lonafarnib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop tumor cells from dividing so they stop growing or die. Giving lonafarnib together with temozolomide may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of lonafarnib when given together with temozolomide in treating patients with recurrent primary supratentorial glioma.

Timeline

Start

2004-03

Primary completion

2009-06

Completion

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Drugs

Indications