drugset / Trial / NCT00091039

Vaccine Therapy, Chemotherapy, and Radiation Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed With Surgery

NCT00091039

Treatment

Summary

RATIONALE: Vaccines made from a gene-modified virus may make the body build an immune response to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high energy x-rays to damage tumor cells. Combining vaccine therapy with chemotherapy and radiation therapy may kill more tumor cells. PURPOSE: This clinical trial is studying how well giving vaccine therapy together with paclitaxel, carboplatin, and radiation therapy works in treating patients with stage III non-small cell lung cancer that cannot be removed with surgery.

Timeline

Start
2004-08
Primary completion
Completion
2006-02

Drugs

EvaluationDrugModalityDoseRoute
Subject Carboplatin Small molecule Intravenous
Subject Paclitaxel Small molecule Intravenous
Subject recombinant fowlpox GM-CSF vaccine Vaccine Subcutaneous
Subject recombinant fowlpox-CEA(6D)/TRICOM vaccine Vaccine Subcutaneous
Subject recombinant vaccinia-CEA(6D)-TRICOM vaccine Vaccine Subcutaneous

Indications