Dopaminergic Enhancement of Learning and Memory in Aphasia

Phase 4 Completed 12 enrolled University Hospital Muenster German Federal Ministry of Education and Research · collab

RandomizedCrossoverTriple-blindTreatment

Summary

The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.

Timeline

Start: 2005-01
Primary completion: 2007-02
Completion: 2008-12

Outcome

Missed primary endpoint

paper L-dopa does not add to the success of high-intensity language training in aphasia. PMID 25588456 ↗

paper l-dopa had no incremental effect to intensive training. PMID 25588456 ↗

Publications

Background Knecht S, Breitenstein C, Bushuven S, Wailke S, Kamping S, Floel A, Zwitserlood P, Ringelstein EB. Levodopa: faster and better word learning in normal humans. Ann Neurol. 2004 Jul;56(1):20-6. doi: 10.1002/ana.20125.
Background Breitenstein C, Wailke S, Bushuven S, Kamping S, Zwitserlood P, Ringelstein EB, Knecht S. D-amphetamine boosts language learning independent of its cardiovascular and motor arousing effects. Neuropsychopharmacology. 2004 Sep;29(9):1704-14. doi: 10.1038/sj.npp.1300464.
Background Breitenstein C, Knecht S. [Language acquisition and statistical learning]. Nervenarzt. 2003 Feb;74(2):133-43. doi: 10.1007/s00115-002-1466-1. German.
Breitenstein C, Korsukewitz C, Baumgartner A, Floel A, Zwitserlood P, Dobel C, Knecht S. L-dopa does not add to the success of high-intensity language training in aphasia. Restor Neurol Neurosci. 2015;33(2):115-20. doi: 10.3233/RNN-140435.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Levodopa	Unknown	100 mg	—