Divalproex Sodium in the Treatment of PTSD (Post-Traumatic Stress Disorder)

Phase 3 Completed 101 enrolled VA Office of Research and Development

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purposes of this study are: * To study the efficacy of divalproex in the treatment of PTSD; * To study the plasma GABA (gamma aminobutyric acid) levels before and after treatment with divalproex in PTSD.

Timeline

Start: 2003-10
Primary completion: 2005-08
Completion: 2005-09

Outcome

Missed primary endpoint

paper There were no significant intergroup differences in primary or secondary end points. PMID 18204347 ↗

Publications

Davis LL, Davidson JR, Ward LC, Bartolucci A, Bowden CL, Petty F. Divalproex in the treatment of posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial in a veteran population. J Clin Psychopharmacol. 2008 Feb;28(1):84-8. doi: 10.1097/JCP.0b013e318160f83b.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Divalproex Sodium	Small molecule	500 mg	—