Insulin Resistance and Testosterone in Women

Phase 2 Completed 35 enrolled University of Pennsylvania National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab National Institute on Aging (NIA) · collab TAP Pharmaceutical Products Inc. · collab The John A. Hartford Foundation · collab University of Pennsylvania Diabetes and Endocrinology Research Center (DERC) · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this research study is to determine if a relationship between insulin resistance (IR) and testosterone (T) exists in women who have already gone through menopause.

Timeline

Start: 2005-07
Primary completion: 2011-12
Completion: 2011-12

Publications

Background Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002 Jan 16;287(3):356-9. doi: 10.1001/jama.287.3.356.
Background Golden SH, Ding J, Szklo M, Schmidt MI, Duncan BB, Dobs A. Glucose and insulin components of the metabolic syndrome are associated with hyperandrogenism in postmenopausal women: the atherosclerosis risk in communities study. Am J Epidemiol. 2004 Sep 15;160(6):540-8. doi: 10.1093/aje/kwh250.
Background Larsson H, Ahren B. Androgen activity as a risk factor for impaired glucose tolerance in postmenopausal women. Diabetes Care. 1996 Dec;19(12):1399-403. doi: 10.2337/diacare.19.12.1399.
Background Oh JY, Barrett-Connor E, Wedick NM, Wingard DL; Rancho Bernardo Study. Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo study. Diabetes Care. 2002 Jan;25(1):55-60. doi: 10.2337/diacare.25.1.55.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Leuprolide	Other / unclassified	3.75 mg	Other
Subject	Metformin	Small molecule	1000 mg	Oral

Indications

No indication recorded.