Viagra in the Treatment of Primary Dysmenorrhea

Phase 1/2 Completed 25 enrolled Milton S. Hershey Medical Center National Institutes of Health (NIH) · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

The primary hypothesis is that a 100mg single dose of sildenafil citrate (Viagra) will have a higher improvement rate when compared to placebo in the treatment of moderate to severe primary dysmenorrhea.

Timeline

Start: 2007-05
Primary completion: 2011-06
Completion: 2011-08

Outcome

Met primary endpoint

registry MEAN Sildenafil Citrate: 11.9 (Standard Deviation 3.2) units on a scale NCT00123162 ↗

registry Sildenafil Citrate vs Placebo; p <0.001; Mean Difference (Net) 5.3 (95% CI 2.9 to 7.6); ANCOVA NCT00123162 ↗

Publications

Dmitrovic R, Kunselman AR, Legro RS. Sildenafil citrate in the treatment of pain in primary dysmenorrhea: a randomized controlled trial. Hum Reprod. 2013 Nov;28(11):2958-65. doi: 10.1093/humrep/det324. Epub 2013 Aug 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sildenafil	Unknown	100 mg	Other