drugset / Trial / NCT00127218
High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The purpose of this study is to investigate the added benefits of increased high-density lipoprotein (HDL) cholesterol serum levels over and above those achieved by lipid lowering therapy guided by current guidelines, in older individuals with cardiovascular disease.
Timeline
- Start
- 2003-09
- Primary completion
- 2008-12
- Completion
- 2008-12
Publications
- Background Guyton JR, Goldberg AC, Kreisberg RA, Sprecher DL, Superko HR, O'Connor CM. Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia. Am J Cardiol. 1998 Sep 15;82(6):737-43. doi: 10.1016/s0002-9149(98)00448-2.
- Background Ballantyne CM, Herd JA, Ferlic LL, Dunn JK, Farmer JA, Jones PH, Schein JR, Gotto AM Jr. Influence of low HDL on progression of coronary artery disease and response to fluvastatin therapy. Circulation. 1999 Feb 16;99(6):736-43. doi: 10.1161/01.cir.99.6.736.
- Background Brown BG, Zhao XQ, Chait A, Fisher LD, Cheung MC, Morse JS, Dowdy AA, Marino EK, Bolson EL, Alaupovic P, Frohlich J, Albers JJ. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med. 2001 Nov 29;345(22):1583-92. doi: 10.1056/NEJMoa011090.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Niacin | Small molecule | — | — |
| Background | Atorvastatin | Small molecule | 20 mg | — |
| Background | Fluvastatin | Other / unclassified | 80 mg | — |
| Background | Pravastatin | Small molecule | 80 mg | — |
| Background | Rosuvastatin | Small molecule | 20 mg | — |
| Background | Simvastatin | Small molecule | 20 mg | — |