drugset / Trial / NCT00139633
Selective Dose Escalation for Esophageal Cancer
Non-randomizedSingle-groupOpen-labelTreatment
Summary
This prospective study was designed to assess the outcomes (survival and failure patterns) of therapy for localized esophageal cancer with conventional dose radiation (RT; 50.4 Gy) with concurrent continuous infusion 5-fluorouracil (5-FU) and weekly carboplatin/paclitaxel. Patients with less than complete response (CR) or partial response (PR) received dose escalation of radiation to 59.4 Gy with the same chemotherapy.
Timeline
- Start
- 2000-07
- Primary completion
- —
- Completion
- 2005-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Carboplatin | Small molecule | 2 unknown | Intravenous |
| Subject | Paclitaxel | Small molecule | 45 mg/m2 | Intravenous |
| Subject | fluorouracil | Small molecule | 225 mg/m2 | — |