drugset / Trial / NCT00163852
Treatment of Metabolic Alkalosis in Acute Exacerbations of Cystic Fibrosis
Phase 2/3
Unknown
40 enrolled
Bayside Health
Cystic Fibrosis Federation Australia · collabMonash University · collabNational Health and Medical Research Council, Australia · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
Adult cystic fibrosis (CF) patients admitted with an acute infection complicated by acid-base disturbance and decreased ventilation will be studied. They will receive salt replacement to correct the acid-base disturbance and possibly their ventilation. Assessment of symptoms (questionnaire), acid-base and electrolyte status (blood and urine tests) ventilation (overnight oxygen and carbon dioxide monitoring non-invasively) and sleep-wake pattern (actigraphy) will be carried out. Study hypothesis: Acute volume and electrolyte replacement corrects hypochloremic hypovolemic metabolic alkalosis and compensatory hypoventilation/ hypercapnia in acute exacerbations of cystic fibrosis.
Timeline
- Start
- 2004-02
- Primary completion
- —
- Completion
- 2006-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | sodium chloride | Unknown | — | Intravenous |