Stem Cell Transplantation for Fanconi Anemia

Phase 1/2 Terminated 16 enrolled Masonic Cancer Center, University of Minnesota

Non-randomizedSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to determine whether thymic shielding during total body irradiation can be given and whether it will reduce the risk of infections in Fanconi Anemia patients undergoing alternate donor (not a matched sibling) stem cell transplants.

Timeline

Start: 2004-03
Primary completion: 2008-12
Completion: 2008-12

Outcome

Outcome not reported

Stopped: “Treatment with thymic shielding found safe, another study started.”

Publications

MacMillan ML, DeFor TE, Young JA, Dusenbery KE, Blazar BR, Slungaard A, Zierhut H, Weisdorf DJ, Wagner JE. Alternative donor hematopoietic cell transplantation for Fanconi anemia. Blood. 2015 Jun 11;125(24):3798-804. doi: 10.1182/blood-2015-02-626002. Epub 2015 Mar 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Background	Cyclophosphamide	Other / unclassified	—	Intravenous
Background	Fludarabine	Small molecule	—	Intravenous