Enteral Glutamine Supplementation for the Patient With Major Torso Trauma

Phase 1 Terminated 20 enrolled The University of Texas Health Science Center, Houston National Institutes of Health (NIH) · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

Glutamine is considered a conditionally essential amino acid during critical illness. After severe trauma, glutamine supplementation into the gastrointestinal tract may help maintain bowel function. We hypothesize that for the major torso trauma patient, high dose glutamine given enterally during resuscitation from shock and continued during enteral nutrition support is absorbed, available systemically and preserves gut integrity.

Timeline

Start: 2005-06
Primary completion: —
Completion: 2006-09

Publications

Background McQuiggan M, Kozar R, Sailors RM, Ahn C, McKinley B, Moore F. Enteral glutamine during active shock resuscitation is safe and enhances tolerance of enteral feeding. JPEN J Parenter Enteral Nutr. 2008 Jan-Feb;32(1):28-35. doi: 10.1177/014860710803200128.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Glutamine	Other / unclassified	—	Other

Indications

No indication recorded.