The Role of Acute Combined PPAR Alpha and Gamma Stimulation on Insulin Action in Humans

Summary

The purpose of this study is to investigate the acute effects of the thiazolidinedione agent pioglitazone (which has combined PPAR alpha and gamma stimulation) on insulin's ability to suppress glucose production, stimulated glucose uptake, and impact a number of other metabolically important endpoints, including production of adiponectin (a protein hormone which regulates sugar levels and fatty acid breakdown) in subjects with type 2 diabetes.

Timeline

Start

2000-12

Primary completion

2011-07

Completion

2011-07

Drugs

Indications