Clinical Trial of the Use of Intraperitoneal Local Anaesthetic

Phase 3 Completed 80 enrolled Imperial College London

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Patients undergoing keyhole gall bladder removal will be divided into 3 groups, one control, one will have local anaesthetic and the third will have normal saline nebulised into their abdomen before closure of the wounds to reduce postoperative pain. These medications will be given on top of the standard pain management protocol.

Timeline

Start: 2004-10
Primary completion: 2005-09
Completion: 2005-09

Publications

Results Alkhamesi NA, Peck DH, Lomax D, Darzi AW. Intraperitoneal aerosolization of bupivacaine reduces postoperative pain in laparoscopic surgery: a randomized prospective controlled double-blinded clinical trial. Surg Endosc. 2007 Apr;21(4):602-6. doi: 10.1007/s00464-006-9087-6. Epub 2006 Dec 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Bupivacaine	Other / unclassified	3 mg/kg	Other
Comparator	Bupivacaine	Other / unclassified	10 ml	Other

Indications

No indication recorded.