Fixed Dose Heparin Study

Phase 3 Completed 866 enrolled McMaster University Heart and Stroke Foundation of Ontario · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

FIDO was a multicentred randomized, open-label trial that compared fixed-dose UFH with fixed-dose LMWH for initial treatment of VTE. Patients were followed for 3 months during which they received warfarin (target INR 2.0-3.0).

Timeline

Start: 1998-09
Primary completion: —
Completion: 2004-05

Publications

Results Kearon C, Ginsberg JS, Julian JA, Douketis J, Solymoss S, Ockelford P, Jackson S, Turpie AG, MacKinnon B, Hirsh J, Gent M; Fixed-Dose Heparin (FIDO) Investigators. Comparison of fixed-dose weight-adjusted unfractionated heparin and low-molecular-weight heparin for acute treatment of venous thromboembolism. JAMA. 2006 Aug 23;296(8):935-42. doi: 10.1001/jama.296.8.935.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dalteparin sodium	Other / unclassified	100 iu/kg	Subcutaneous
Subject	Enoxaparin sodium	Other / unclassified	100 iu/kg	Subcutaneous
Subject	Heparin	Other / unclassified	250 iu/kg	Subcutaneous

Fixed Dose Heparin Study

Summary

Timeline

Publications

Drugs

Indications