Drugs / Dalteparin sodium
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Dalteparin sodium

Other / unclassified targets SERPINC1 via activation

Developed for
venous thromboembolism · pulmonary embolism · thrombotic disease · COVID-19 · malignant pancreatic neoplasm · cancer · colorectal cancer · lung cancer
+29 more · blood coagulation disease · plasma cell myeloma · pneumonia · ulcer of lower limbs · antiphospholipid syndrome · atrial fibrillation · breast cancer · cardiac valvular defect · central nervous system neoplasm · clear cell sarcoma of kidney · esophageal cancer · habitual spontaneous abortion · intermediate coronary syndrome · myocardial infarction · nephrotic syndrome · pregnancy disorder · pregnancy loss, recurrent, 4 · prostate cancer · renal cell carcinoma · sickle cell disease · carotid artery dissection · infectious disease with sepsis · ovarian carcinoma · pregnancy disorder with abortive outcome · stroke disorder · thrombophilia · thrombophlebitis · traumatic brain injury · vertebral artery dissection
Investigated by
Pfizer · Canadian Institutes of Health Research (CIHR) · National Cancer Institute (NCI) · Eisai Inc. · M.D. Anderson Cancer Center · McMaster University
+84 more · Canadian Critical Care Trials Group · Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network · Duke University · Helsinki University Central Hospital · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Mount Sinai Hospital, Canada · National Heart, Lung, and Blood Institute (NHLBI) · Ottawa Hospital Research Institute · Unity Health Toronto · University of Aarhus · University of Manitoba · University of Southern California · University of Vermont Medical Center · Aarhus University Hospital · Academic and Community Cancer Research United · Academy of Finland · Al Ain Hospital · Alberta Health services · Alliance for Clinical Trials in Oncology · Aotearoa Clinical Trials · Aurora Clinical Research · Australasian Society for Infectious Diseases · Australian and New Zealand Intensive Care Research Centre · Avanti PC · Barnes-Jewish Hospital · Beijing Friendship Hospital · Brookdale University Hospital Medical Center · Cardiff University · Celgene Corporation · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal · Eastern Cooperative Oncology Group · Foothills Medical Centre · GERCOR - Multidisciplinary Oncology Cooperative Group · Gary Morrow · Hamilton Health Sciences Corporation · Heart and Stroke Foundation of Ontario · Hopital Charles Lemoyne · Hull University Teaching Hospitals NHS Trust · Hunter Medical Research Institute · Imperial College London · Jonsson Comprehensive Cancer Center · Josephine Ford Cancer Center · King Fahad Medical City · King Faisal Specialist Hospital & Research Center · King Saud Medical City · MOUNT SINAI HOSPITAL · Maisonneuve-Rosemont Hospital · Marc Blondon · Mater Misericordiae University Hospital · Medical University of Vienna · Michael Garron Hospital · National Institute for Health Research, United Kingdom · Ontario Clinical Oncology Group (OCOG) · Ozmosis Research Inc. · Peter Lougheed Centre · Queen Elizabeth II Health Sciences Centre · Research Manitoba · Roswell Park Cancer Institute · Southlake Health · St. Joseph's Health Centre Toronto · Sunnybrook Health Sciences Centre · Suzanne C. Cannegieter, MD PhD · The Finnish Medical Association · The Ottawa Hospital · The Peter Doherty Institute for Infection and Immunity · Thomas Decker Christensen · Trillium Health Partners · Tzu-Fei Wang · University Health Network, Toronto · University Hospital, Brest · University of Alberta · University of Calgary · University of Jena · University of Melbourne · all 90 on the full record

Regulatory milestones approvals, filings & regulatory actions · 8 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (7) US (FDA) FRAGMIN 1996-03-18 – 2024-10-15 fda.gov
Approved US (FDA) FRAGMIN 1994-12-22 fda.gov

Trials 57 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT01061411 Feb 2010 → Oct 2015 clear cell sarcoma of kidney, renal cell carcinoma Roswell Park Cancer Institute Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT04850378 Mar 2021 → May 2024 nephrotic syndrome, thrombotic disease University of Aarhus Completed No outcome recorded
Phase 1/2 NCT02334007 Sep 2015 → Sep 2018 lung neoplasm, pulmonary embolism, venous thromboembolism McMaster University Completed No outcome recorded
Phase 211 trials
Phase 2 NCT03297359 Mar 2018 → Nov 2023 cancer, obesity disorder, venous thromboembolism Ottawa Hospital Research Institute Terminated No outcome recorded
Phase 2 NCT03200613 Sep 2017 → Jul 2019 spinal cord injury, venous thromboembolism McMaster University Terminated No outcome recorded
Phase 2 NCT01817257 Dec 2013 → Feb 2015 cancer, pulmonary embolism, thrombotic disease, venous thromboembolism Cardiff University Terminated No outcome recorded
Phase 2 NCT01518465 Jan 2012 → Dec 2016 plasma cell myeloma University of Southern California Terminated No outcome recorded
Phase 2 NCT01419977 May 2011 → Jul 2013 sickle cell disease Duke University Completed No outcome recorded
Phase 2 NCT00952380 Aug 2009 → Mar 2018 venous thromboembolism Pfizer Completed No outcome recorded
Phase 2 NCT00323011 May 2006 → Nov 2007 colorectal cancer University of Southern California Terminated No outcome recorded
Phase 2 NCT00462852 Apr 2003 → Nov 2011 pancreatic adenocarcinoma, venous thromboembolism Hull University Teaching Hospitals NHS Trust Completed No outcome recorded
Phase 2 NCT00216866 Sep 2002 → Mar 2006 venous thromboembolism London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Completed No outcome recorded
Phase 2 NCT00028678 Jul 2002 → Jul 2006 central nervous system neoplasm Eastern Cooperative Oncology Group Completed No outcome recorded
Phase 2/33 trials
Phase 2/3 NCT04372589 May 2020 → May 2021 COVID-19, pneumonia University of Manitoba Completed No outcome recorded
Phase 2/3 NCT00765063 Oct 2008 → Oct 2010 ulcer of lower limbs Pfizer Completed No outcome recorded
Phase 2/3 NCT00662831 Apr 2008 → Oct 2010 ulcer of lower limbs Pfizer Completed No outcome recorded
Phase 320 trials
Phase 3 NCT07140211 Oct 2025 → Aug 2030 expected puerperal disorder, venous thromboembolism Marc Blondon Recruiting No outcome recorded
Phase 3 NCT06494878 Apr 2025 → Aug 2030 expected venous thromboembolism University of Calgary Not yet recruiting No outcome recorded
Phase 3 NCT05848713 Oct 2023 → Mar 2028 expected pneumonia University of Manitoba Recruiting No outcome recorded
Phase 3 NCT04483960 Jul 2020 → Jul 2025 COVID-19 University of Melbourne Unknown No outcome recorded
Phase 3 NCT04444700 Jul 2020 → May 2021 COVID-19, blood coagulation disease, severe acute respiratory syndrome, venous thromboembolism University of Sao Paulo General Hospital Completed No outcome recorded
Phase 3 NCT04362085 May 2020 → May 2021 COVID-19 Unity Health Toronto Completed No outcome recorded
Phase 3 NCT02585713 Nov 2015 → Apr 2018 cerebral sinovenous thrombosis, hepatic vein thrombosis, isolated mesenteric vein thrombosis, isolated splenic vein thrombosis +4 Academic and Community Cancer Research United Completed No outcome recorded
Phase 3 NCT01879618 Oct 2013 → Mar 2016 chronic renal failure syndrome Pfizer Completed No outcome recorded
Phase 3 NCT01274637 Mar 2011 → Jan 2014 puerperal disorder, venous thromboembolism Ottawa Hospital Research Institute Completed No outcome recorded
Phase 3 NCT00876915 Jul 2009 → Jul 2014 pulmonary embolism, venous thromboembolism University of Rochester Terminated No outcome recorded
Phase 415 trials
Phase 4 NCT06845423 May 2025 → May 2028 expected venous thromboembolism University Hospital, Brest Recruiting No outcome recorded
Phase 4 NCT05735639 Jan 2024 → Jun 2027 expected varicose disease, venous thromboembolism Imperial College London Recruiting No outcome recorded
Phase 4 NCT05255003 Aug 2022 → Dec 2026 expected blood coagulation disease, thrombocytopenia Tzu-Fei Wang Recruiting No outcome recorded
Phase 4 NCT05245877 Aug 2022 → Aug 2026 overdue hemorrhagic disease, malignant pancreatic neoplasm, thrombotic disease Helsinki University Central Hospital Recruiting No outcome recorded
Phase 4 NCT05067153 May 2021 → May 2023 esophageal cancer, thrombotic disease, venous thromboembolism University of Aarhus Unknown No outcome recorded
Phase 4 NCT04731558 Feb 2021 → Feb 2027 expected hemorrhagic disease, liver cancer, pulmonary embolism, venous thromboembolism Helsinki University Central Hospital Recruiting No outcome recorded
Phase 4 NCT02607111 Aug 2016 → Jul 2018 kidney failure London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Completed No outcome recorded
Phase 4 NCT01741506 Mar 2013 → Apr 2015 lung cancer Thomas Decker Christensen Completed No outcome recorded
Phase 4 NCT00966277 Apr 2010 → Sep 2014 malignant pancreatic neoplasm, venous thromboembolism M.D. Anderson Cancer Center Completed No outcome recorded
Phase 4 NCT00942968 Jun 2009 → Mar 2012 cancer Pfizer Completed No outcome recorded
Phase not applicable5 trials
NCT07658989 May 2026 → Jan 2030 expected cardiac valvular defect, pregnancy disorder Mount Sinai Hospital, Canada Recruiting No outcome recorded
NCT06583330 Oct 2024 → Jan 2027 expected colorectal cancer, venous thromboembolism Beijing Friendship Hospital Not yet recruiting No outcome recorded
NCT01542762 Mar 2012 → Jul 2016 pulmonary embolism, venous thromboembolism Suzanne C. Cannegieter, MD PhD Completed No outcome recorded
NCT00525057 Jul 2006 → Jun 2020 bone sarcoma, metastatic neoplasm, plasma cell myeloma, soft tissue sarcoma M.D. Anderson Cancer Center Completed No outcome recorded
NCT00564174 Mar 2000 → Sep 2005 antiphospholipid syndrome, pregnancy loss, recurrent, 4 Mount Sinai Hospital, Canada Terminated No outcome recorded
Also used as a comparator or background therapy in 36 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT03100123 Comparator Nov 2017 → Oct 2019 antiphospholipid syndrome, pregnancy disorder with abortive outcome Ottawa Hospital Research Institute Terminated No outcome recorded
Phase 25 trials
Phase 2 NCT05189002 Comparator May 2019 → Aug 2021 venous thromboembolism PharmaDiall Ltd. Unknown No outcome recorded
Phase 2 NCT03178864 Comparator Mar 2019 → Oct 2022 cerebral sinovenous thrombosis University of British Columbia Completed No outcome recorded
Phase 2 NCT03139487 Comparator Aug 2017 → Sep 2021 ampulla of vater cancer, esophageal cancer, gastric cancer, gastroesophageal cancer +3 Asan Medical Center Unknown No outcome recorded
Phase 2 NCT01648036 Comparator Jul 2012 → Jan 2014 infectious disease with sepsis University of Manitoba Completed No outcome recorded
Phase 2 NCT00239980 Comparator Oct 2005 → Jan 2010 ovarian carcinoma Ontario Clinical Oncology Group (OCOG) Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT00260988 Comparator Oct 2003 → Nov 2008 thrombotic disease Ottawa Hospital Research Institute Completed No outcome recorded
Phase 316 trials
Phase 3 NCT07228663 Comparator Dec 2025 → Jul 2027 expected venous thromboembolism McMaster University Not yet recruiting No outcome recorded
Phase 3 NCT06370273 Comparator Nov 2024 → Aug 2028 expected thrombotic disease Queen Mary University of London Recruiting No outcome recorded
Phase 3 NCT06153394 Comparator Jun 2024 → Feb 2025 overdue liver disorder, thrombophilia, thrombotic disease Western University, Canada Not yet recruiting No outcome recorded
Phase 3 NCT05171075 Comparator Sep 2022 → Apr 2026 pulmonary embolism, venous thromboembolism Anthos Therapeutics, Inc. Terminated No outcome recorded
Phase 3 NCT04536272 Comparator Oct 2020 → Mar 2025 heart failure, hemorrhagic disease, respiratory failure, thrombotic disease University Medical Center Groningen Completed No outcome recorded
Phase 46 trials
Phase 4 NCT06020560 Comparator Mar 2023 → Mar 2025 venous thromboembolism Herlev Hospital Unknown No outcome recorded
Phase 4 NCT01828697 Comparator Apr 2013 → Oct 2021 pulmonary embolism, venous thromboembolism Academic Medical Center - University of Amsterdam Completed No outcome recorded
Phase 4 NCT01245998 Comparator Dec 2010 → Dec 2012 thrombophlebitis University Medical Centre Ljubljana Completed No outcome recorded
Phase 4 NCT01714297 Comparator Jan → Jun 2008 infectious disease Vestre Viken Hospital Trust Completed No outcome recorded
Phase 4 NCT00655122 Comparator Apr → Dec 2003 hyperheparinemia, venous thromboembolism Pfizer Terminated No outcome recorded
Phase not applicable7 trials
NCT05058924 Comparator Aug 2021 → Feb 2024 venous thromboembolism Mount Sinai Hospital, Canada Completed No outcome recorded
NCT03671174 Background Aug 2019 → Sep 2021 habitual spontaneous abortion, undifferentiated connective tissue syndrome RenJi Hospital Unknown No outcome recorded
NCT03465735 Background Jan 2017 → Aug 2019 venous thromboembolism Mayo Clinic Terminated No outcome recorded
NCT02744092 Comparator Dec 2016 → Oct 2020 cancer, pulmonary embolism, thrombotic disease, venous thromboembolism Alliance Foundation Trials, LLC. Completed No outcome recorded
NCT01050153 Comparator Mar 2010 → Dec 2011 venous thromboembolism Denver Health and Hospital Authority Completed No outcome recorded

Evidence & citations 28 cited values

Every value below carries the sentence it was read from. 95 sources stand behind the page.

FieldValueCited text
Known as Dalteparin sodium “BACKGROUND: Dalteparin sodium, a low-molecular-weight heparin, is indicated for prevention of clotting in the extracorporeal circuit during hemodialysis (HD).” PMID 30542622 Nov 2018
8

Dalteparin sodium was administered at a daily dosage of 5,000 UI anti-Xa by subcutaneous route.” NCT00655122

“Pre-filled syringes containing a single dose of 5000 IU Fragmin/ Dalteparin Sodium.” NCT00662831

“Pre-filled syringes containing a single dose of 5000 IU Fragmin/ Dalteparin SodiumNCT00765063

Dalteparin sodium (Fragmin)” NCT01050153

“Fragmin (Dalteparin Sodium)” NCT00564174

NCT00400387

NCT00264381

NCT01274637

Known as .alpha.-heparin ChEMBL registry synonym — accepted as the source's own label CHEMBL1201460
Known as B01AB04 ChEMBL registry synonym — accepted as the source's own label CHEMBL1201460
Known as Boxol ChEMBL registry synonym — accepted as the source's own label CHEMBL1201460
Known as Dalteparin “The initial dose will be a twice daily therapeutic dose of 1.35U/kg (pregnancy weight) of enoxaparin or 135 U/kg (pregnancy weight) of dalteparin using prefilled syringes...” NCT07658989
79

“Enoxaparin, dalteparin, or tinzaparin are acceptable LMWHs to be used for patients in the investigational arm and dose should be based on measured or estimated weight of the patient.” NCT05848713

“BACKGROUND: Dalteparin sodium, a low-molecular-weight heparin, is indicated for prevention of clotting in the extracorporeal circuit during hemodialysis (HD).” PMID 30542622 Nov 2018

“LMWHs like Nadroparin and Dalteparin are no experimental pharmaceuticals; both have been registered in the Netherlands for these indications since 1989.” NCT01542762

“Enoxaparin 40mg once daily subcutaneous or dalteparin 5000IU once daily subcutaneous or nadroparin calcium 4100U once daily subcutaneous” NCT03671174

“Low-molecular-weight heparin (dalteparin or enoxaparin) was administered subcutaneously at a dose of 100 IU/kg every 12 hours (n = 352).” PMID 16926353 Aug 2006

dalteparin, 200 IU/kg subcutaneously once daily for one month followed by 150 IU/kg subcutaneously once daily for 2 months” NCT02746185

“Enoxaparin 40 mg/dalteparin 5000 U/tinzaparin 4500 U subcutaneously daily for women with weight \<100 kg for 6 weeks.” NCT05058924

“or dalteparin (200 IU/kg subcutaneous once daily or 100 IU/kg subcutaneous twice a day)” NCT04372589

Dalteparin 5000 units daily or Enoxaparin 40 mg subcutaneous daily” NCT03200613

“Low-molecular weight heparin (dalteparin, enoxaparin, tinzaparin)” NCT03178864

“LMWH options include: Tinzaparin, Enoxaparin, or Dalteparin.” NCT04444700

“LMWH options include: Tinzaparin, Enoxaparin or Dalteparin.” NCT04362085

Dalteparin, Enoxaparin, Nadroparin, Tinzaparin” NCT06494878

Dalteparin: 5000 IU subcutaneously OD” NCT07228663

Dalteparin 200 I.E./kg BW once daily” NCT02583191

dalteparin 5000-7500IU o.d.” NCT07140211

“Fragmin (Dalteparin Sodium)” NCT00564174

Dalteparin (Fragmin®)” NCT01817257

Dalteparin (Fragmin)” NCT03465735

DalteparinNCT01419977

dalteparinNCT01164046

DalteparinNCT03100123

NCT01741506

NCT02585713

NCT05171075

NCT00435487

NCT00519805

NCT04483960

NCT01714297

NCT00432796

NCT06153394

NCT00216866

NCT00942968

NCT06370273

NCT00238667

NCT00655122

NCT00135876

NCT01828697

NCT05735639

NCT00445328

NCT01050153

NCT02073682

NCT00182143

NCT00966277

NCT00437697

NCT00003674

NCT00245856

NCT04731558

NCT02607111

NCT01648036

NCT03297359

NCT02334007

NCT00182364

NCT01245998

NCT00462852

NCT00726570

NCT00041782

NCT01061411

NCT03045406

NCT03559114

NCT00187408

NCT00662831

NCT00239980

NCT02744092

NCT00876915

NCT00031837

NCT01518465

NCT03139487

NCT00028678

NCT05245877

NCT05255003

NCT06020560

NCT06583330

NCT00967382

NCT00525057

NCT04850378

NCT00952380

NCT00260988

NCT00786474

Known as Dalteparin (Fragmin) “Dalteparin (Fragmin®)” NCT01817257
1

Dalteparin (Fragmin)NCT03465735

Known as Dalteparin sodium (Fragmin) Dalteparin sodium (Fragmin)NCT01050153
Known as DALTEPARIN SODIUM INJECTION “A THREE MONTH PROSPECTIVE OPEN LABEL STUDY OF THERAPY WITH FRAGMIN(REGISTERED) (DALTEPARIN SODIUM INJECTION) IN CHILDREN WITH VENOUS THROMBOEMBOLISM WITH OR WITHOUT MALIGNANCIES” NCT00952380
Known as Dalteparin Sodium(DIN 02132648/NDC# 62856-500) Dalteparin Sodium(DIN 02132648/NDC# 62856-500)NCT01274637
Known as Dalteparina de sodio ChEMBL registry synonym — accepted as the source's own label CHEMBL1201460
Known as dalteparine Dalteparine 5000 UI” NCT06845423
3

DalteparineNCT04536272

NCT00681785

NCT00662688

Known as Dalteparine sodique ChEMBL registry synonym — accepted as the source's own label CHEMBL1201460
Known as FR-860 ChEMBL registry synonym — accepted as the source's own label CHEMBL1201460
Known as Fragmin “The FRAGMATIC trial will assess the effect of adding dalteparin (FRAGMIN), a type of LMWH, to standard treatment for patients with lung cancer.” PMID 19807917 Oct 2009
15

“Pre-filled syringes containing a single dose of 5000 IU Fragmin/ Dalteparin Sodium.” NCT00662831

Fragmin for the Treatment of Acute VTE in Pediatric Cancer Patients” NCT00952380

“Dalteparin (Fragmin®) 5000 IU (International Unit) once daily” NCT01741506

Fragmin (Dalteparin) LMWH verus Unfractionated Heparin (UFH)” NCT00182364

Fragmin (Dalteparin Sodium)” NCT00564174

“Drug: Fragmin (dalteparin)” NCT00260988

“dalteparine (Fragmin)” NCT00681785

“Dalteparin ( Fragmin)” NCT00435487

“Dalteparin (Fragmin)” NCT00445328

“Dalteparin (Fragmin)” NCT00041782

NCT00006083

NCT00323011

NCT05189002

NCT05067153

NCT00765063

Known as Fragmin (Dalteparin Sodium) Fragmin (Dalteparin Sodium)NCT00564174
Known as Fragmin P Forte Fragmin P Forte (dalteparin sodium)” NCT00400387
Known as FRAGMIN(REGISTERED) “A THREE MONTH PROSPECTIVE OPEN LABEL STUDY OF THERAPY WITH FRAGMIN(REGISTERED) (DALTEPARIN SODIUM INJECTION) IN CHILDREN WITH VENOUS THROMBOEMBOLISM WITH OR WITHOUT MALIGNANCIES” NCT00952380
Known as Fragmine ChEMBL registry synonym — accepted as the source's own label CHEMBL1201460
Known as HEPARIN FRAGMENT KABI 2165 ChEMBL registry synonym — accepted as the source's own label CHEMBL1201460
Known as KABI-2165 ChEMBL registry synonym — accepted as the source's own label CHEMBL1201460
Known as Low liquemine ChEMBL registry synonym — accepted as the source's own label CHEMBL1201460
Known as nadroparine Nadroparine 2850 UI” NCT06845423
2

NadroparineNCT04536272

NCT00421538

Known as nadroparine calcium “Once-daily injection of 171 U/Kg/day of nadroparine calcium for 6 weeks.” NCT00421538
Action Activate “Antithrombin-III activator” CHEMBL1201460
Action Inhibit “Dalteparin may be effective in inhibiting the growth of blood vessels in tumors” NCT00003674