PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST)

Summary

This is a phase III, multi-centre, double blind, randomized controlled trial of patients with traumatic brain injury (TBI).

Timeline

Start

2018-07-19

Primary completion

2026-12

Completion

2027-12

Publications

• Pirouzmand F, Mathieu F, Mansouri A, Kavikondala K, Alkins R, Boyd JG, Christie S, Couillard P, Cusimano MD, Engels PT, English S, Fourney D, Fowler R, Geerts W, Gooderham PA, Griesdale D, Hunter G, Jabehdar Maralani P, Kelly ME, Klein G, Kramer AH, Kromm J, Kutsogiannis DJ, Lauzier F, Machnowska M, Maslove DM, Mejia-Mantilla J, Midha R, Misra B, Murphy L, O'Kelly CJ, Patel C, Pinto RL, Pronovost AP, Sekhon M, Sharma SV, Sinclair J, Tsai E, Turgeon AF, Warade A, Scales DC; PROTEST investigators. Prophylaxis for venous thromboembolism in traumatic brain injury: protocol for a randomised controlled trial. BMJ Open. 2025 Dec 25;15(12):e114158. doi: 10.1136/bmjopen-2025-114158.

Drugs

Indications