drugset / Trial / NCT07140211

Short-term Low-dose Low-molecular-weight Heparin to Prevent Postpartum Thrombosis

NCT07140211

Phase 3 Recruiting 9200 enrolled Marc Blondon
RandomizedParallel-groupSingle-blindPrevention

Summary

The goal of this clinical trial is to evaluate the risk-benefit of a short-term treatment with a low-dose low-molecular-weight heparin (LMWH), in the postpartum period (after delivery). The main questions it aims to answer are: * compared to no treatment, does short-term postpartum LMWH modify the risk of venous thromboembolism within 90 days of delivery? * compared to no treatment, does short-term postpartum LMWH modify the risks of bleeding and wound complications? Participants will take low-dose LMWH for 7-10 days or no treatment, and will be followed for 90 days post-delivery.

Timeline

Start
2025-10-15
Primary completion
2030-08
Completion
2030-08

Drugs

EvaluationDrugModalityDoseRoute
Subject Dalteparin sodium Other / unclassified 5000 iu
Subject Dalteparin sodium Other / unclassified 7500 iu
Subject Enoxaparin sodium Other / unclassified 4000 iu
Subject Enoxaparin sodium Other / unclassified 6000 iu
Subject Nadroparin Calcium Other / unclassified 3800 iu
Subject Nadroparin Calcium Other / unclassified 5700 iu
Subject Tinzaparin Other / unclassified 4500 iu
Subject Tinzaparin Other / unclassified 7000 iu