Botulinum Toxin Injection in Neck Muscles in Cervicogenic Headache

Phase 2 Completed 28 enrolled Norwegian University of Science and Technology

RandomizedCrossoverDouble-blindTreatment

Summary

The purpose of this study is to investigate the effect and side-effects of injections with botulinum toxin in neck muscles in cervicogenic headache compared to injections with sodium water.

Timeline

Start: 2005-05
Primary completion: 2009-12
Completion: 2009-12

Outcome

Missed primary endpoint

paper no significant difference between verum and placebo in a mixed linear model analysis (p = 0.084) with regard to the primary end-point PMID 21300635 ↗

Publications

Results Linde M, Hagen K, Salvesen O, Gravdahl GB, Helde G, Stovner LJ. Onabotulinum toxin A treatment of cervicogenic headache: a randomised, double-blind, placebo-controlled crossover study. Cephalalgia. 2011 May;31(7):797-807. doi: 10.1177/0333102411398402. Epub 2011 Feb 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Botulinum toxin type A	Protein / enzyme biologic	—	Intramuscular