Drugs / Botulinum toxin type A
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Botulinum toxin type A

Protein / enzyme biologic targets BCL11A, SNAP25, TGFB1, TRPV1 via inhibition

Developed for
overactive bladder · stroke disorder · migraine disorder · cerebral palsy · cervical dystonia · isolated hyperchlorhidrosis · masticatory muscles, hypertrophy of · chronic pain syndrome
+201 more · eyelid disorder · bruxism · myofascial pain syndrome · Parkinson disease · benign essential blepharospasm · salivary substance, Clostridium botulinum type · benign prostatic hyperplasia · skin atrophy · interstitial cystitis · neuropathy, painful · osteoarthritis, knee · plantar fasciitis · spastic cerebral palsy · temporomandibular joint disorder · essential tremor · headache disorder · clubfoot · compartment syndrome · epicondylitis · keloid · achalasia · erectile dysfunction · facial spasm · multiple sclerosis · premature ejaculation · traumatic brain injury · ulcer of anus and rectum · vulvodynia · beta thalassemia · cluster headache syndrome · depressive disorder · diplegia of upper limb · disease of orbital part of eye adnexa · obesity disorder · osteoarthritis · parasomnia, sleep bruxism type · pelvis syndrome · psoriasis · Raynaud disease · rosacea · scrotal disorder · spastic hemiplegia · temporomandibular joint dysfunction syndrome · trigeminal neuralgia · vaginismus · abdominal wall malformation · acne · alopecia areata · amyotrophic lateral sclerosis · androgenetic alopecia · arthritic joint disease · atrial fibrillation · chronic prostatitis · cleft lip · dystonic disorder · esotropia · focal dystonia · major depressive disorder · movement disorder · nervous system disorder · nervous system injury · neuroma · odontoclasia · osteoarthritis, hand · pelvic organ prolapse · persistent idiopathic facial pain · postherpetic neuralgia · reactive cutaneous fibrous lesion · restless legs syndrome · retrograde cricopharyngeus dysfunction · rotator cuff syndrome · sexual disorder · skin disorder · spasmodic dystonia · spastic diplegia · Tented eyebrows · traumatic neuropathy · ulcer of lower limbs · urinary bladder disorder · adolescent idiopathic scoliosis · AIDS dysmorphic syndrome · alopecia totalis · alopecia universalis · anus disorder · arthropathy · atopic eczema · autonomic dysreflexia · baldness, male pattern · bladder neck obstruction · brachial plexus neuropathy · brain stem infarction · burning mouth syndrome · bursitis · cardiac valvular defect · carpal tunnel syndrome · cerebral palsy spastic hemiplegic · chemotherapy-induced neuropathy · chronic rhinosinusitis · chronic tic disorder · complex regional pain syndrome · complex regional pain syndrome type 1 · complex regional pain syndrome type 2 · cranial nerve neuropathy · Darier disease · detrusor sphincter dyssynergia · developmental delay with sleep apnea · diabetes mellitus · disease of the tendon · disorder of pharynx · dry eye syndrome · dyskinesia of esophagus · dysphagia lusoria · empty nose syndrome · endometriosis · epidermolysis bullosa simplex · esophageal disorder · eye disorder · female stress incontinence · fibromyalgia · flushing of ears and somnolence · focal epilepsy · focal stiff limb syndrome · Fowler syndrome · functional gastric disease · gastric neoplasm · gingival disorder · Hailey-Hailey disease · hemicrania continua · hemiplegia · herpes labialis · hidradenitis suppurativa · hyperpigmentation of the skin · ischemic disease · laryngeal granuloma · leiomyoma cutis · levator syndrome · low compliance bladder · migraine without aura · morbid obesity · myelomeningocele · nasal cavity polyp · obstructive sleep apnea syndrome · oromandibular dystonia · outlet dysfunction constipation · pancreas disorder · patellofemoral pain syndrome · peripheral arterial occlusive disease 1 · Peyronie disease · polyarticular arthritis · premature aging syndrome · primary dysmenorrhea · ptosis · social phobia · spastic monoplegia · spinal cord injury · spinal stenosis · systemic sclerosis · testicular disorder · thoracic outlet syndrome · thromboangiitis obliterans · tinnitus · tooth erosion, non-bacterial · Tourette syndrome · traumatic encephalopathy · type 2 diabetes mellitus · vasculogenic impotence · voice disorders · allesthesia · atrial flutter · borderline personality disorder · cerebrovascular disorder · chronic obstructive pulmonary disease · congenital contractures · congenital deformities of limbs · congenital limb malformation · dementia · dermis disorder · diabetic neuropathy · diabetic polyneuropathy · elastoderma · excessive tearing · exotropia · facial paralysis · focal hand dystonia · focal, segmental or multifocal dystonia · gastroparesis · hyperhidrosis palmaris ET plantaris · ischemic stroke · keloid formation · keratoconus · muscle cramps, familial · neuralgia · Nicolau syndrome · palsy · paroxysmal dystonia · perceptual disorders · polyneuropathy · sleep apnea syndrome · toe, misshapen · vascular insufficiency disorder · vitiligo
Investigated by
Allergan · Ipsen · Merz Pharmaceuticals GmbH · AbbVie · Revance Therapeutics, Inc. · Medy-Tox
+409 more · Norwegian University of Science and Technology · St. Olavs Hospital · Assistance Publique - Hôpitaux de Paris · Cairo University · University of British Columbia · Buddhist Tzu Chi General Hospital · Hugel · Stanford University · Galderma R&D · Merz North America, Inc. · University Hospital, Bordeaux · Mayo Clinic · Anterios Inc. · Assiut University · Daewoong Pharmaceutical Co. LTD. · Eirion Therapeutics Inc. · Northwestern University · Benha University · Beth Israel Deaconess Medical Center · Chang Gung Memorial Hospital · Emory University · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Merz Aesthetics GmbH · Tanta University · The Cleveland Clinic · The University of Texas Health Science Center, Houston · University of California, Irvine · Wake Forest University Health Sciences · Western University, Canada · DeNova Research · GlaxoSmithKline · Johns Hopkins University · Karolinska Institutet · Massachusetts General Hospital · Merz Therapeutics GmbH · Minneapolis Veterans Affairs Medical Center · Nantes University Hospital · National Cheng-Kung University Hospital · Oregon Health and Science University · Peking University · University Hospital, Clermont-Ferrand · University Hospitals Cleveland Medical Center · University of Minnesota · University of Washington · University of Wisconsin, Madison · Vanderbilt University · Yale University · Yonsei University · AZ Delta · Alexandria University · Center for Veterans Research and Education · Centre Hospitalier Universitaire de Besancon · Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Columbia University · EdiGene (GuangZhou) Inc. · Evolus, Inc. · Haukeland University Hospital · Hospices Civils de Lyon · Huons Biopharma · Icahn School of Medicine at Mount Sinai · Instituto de Oftalmología Fundación Conde de Valenciana · Islamabad Medical and Dental College · Kaiser Permanente · Kaohsiung Veterans General Hospital. · Latakia University · Mansoura University · Medicis Pharmaceutical Corporation · Ministry of Health, France · Mount Sinai Hospital, Canada · National Institute of Neurological Disorders and Stroke (NINDS) · Nova Scotia Health Authority · Ohio State University · Oslo University Hospital · PPD Development, LP · all 415 on the full record

Regulatory milestones approvals, filings & regulatory actions · 38 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (8) US (FDA) Xeomin 2011-07-20 – 2026-06-25 fda.gov
Label expansions (20) US (FDA) BOTOX COSMETIC 2000-12-21 – 2024-10-18 fda.gov
Label expansion US (FDA) DAXXIFY 2023-08-11 fda.gov
Label expansions (7) US (FDA) DYSPORT 2015-07-15 – 2023-01-12 fda.gov
Approved EU (EMA) Nuceiva 2019-09-27 europa.eu
Approved US (FDA) BOTOX COSMETIC 1991-12-09 fda.gov

Trials 675 · started per year

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 018 trials
Phase 0 NCT07640035 Jul → Dec 2026 expected bruxism Bilecik Seyh Edebali University Not yet recruiting No outcome recorded
Phase 0 NCT06785844 Jul 2025 → Sep 2030 expected Shaare Zedek Medical Center Recruiting No outcome recorded
Phase 0 NCT05997043 Aug 2023 → Jul 2024 Parkinson disease, overactive bladder Zhujiang Hospital Unknown No outcome recorded
Phase 0 NCT06349733 Mar → Oct 2023 Qilu Hospital of Shandong University Completed No outcome recorded
Phase 0 NCT06437912 Mar → Oct 2023 Dezhou Hospital Qilu Hospital of Shandong University Completed No outcome recorded
Phase 0 NCT05485207 Apr 2022 → Feb 2025 interstitial cystitis Stanford University Unknown No outcome recorded
Phase 0 NCT05330078 Mar 2022 → May 2023 keloid University of California, San Diego Completed No outcome recorded
Phase 0 NCT04984317 Feb 2022 → Dec 2026 female stress incontinence Northwell Health Suspended No outcome recorded
Phase 0 NCT04939909 Jul → Dec 2021 benign essential blepharospasm Second Affiliated Hospital, School of Medicine, Zhejiang University Unknown No outcome recorded
Phase 0 NCT04715048 Jan 2021 → May 2025 University of Southern California Unknown No outcome recorded
Phase 137 trials
Phase 1 NCT07645456 Oct 2025 → Apr 2026 benign prostatic hyperplasia Benha University Completed No outcome recorded
Phase 1 NCT06928246 Jul 2025 → Dec 2026 expected atopic eczema Daniel Kaplan Recruiting No outcome recorded
Phase 1 NCT06778421 Mar → Sep 2025 Center for Advanced Facial Plastic Surgery Completed No outcome recorded
Phase 1 NCT06834789 Feb → Nov 2025 AbbVie Completed No outcome recorded
Phase 1 NCT06788158 Sep 2024 → Jan 2025 overdue plantar fasciitis Mexican Social Security Institute Active not recruiting No outcome recorded
Phase 1 NCT05923996 Feb → Jun 2024 skin disorder Assiut University Unknown No outcome recorded
Phase 1 NCT04580238 Dec 2023 → Jan 2025 carotid artery dissection, cerebral sinovenous thrombosis, hemorrhagic stroke, migraine disorder +2 University of Alberta Withdrawn No outcome recorded
Phase 1 NCT05766683 Mar → Jun 2023 overdue Henry Ford Health System Active not recruiting No outcome recorded
Phase 1 NCT05784363 Oct 2022 → Jun 2024 Merz North America, Inc. Completed No outcome recorded
Phase 1 NCT05585398 Oct 2022 → Feb 2023 Merz Pharmaceuticals GmbH Completed No outcome recorded
Phase 1/228 trials
Phase 1/2 NCT06230146 May 2024 → Jan 2026 keloid Assiut University Unknown No outcome recorded
Phase 1/2 NCT05158166 Oct 2023 → Mar 2025 spasmodic dystonia, voice disorders University of California, San Francisco Completed No outcome recorded
Phase 1/2 NCT05512039 May 2023 → Sep 2026 expected overactive bladder Dartmouth-Hitchcock Medical Center Active not recruiting No outcome recorded
Phase 1/2 NCT03991299 Apr 2021 → Feb 2022 obesity disorder, type 2 diabetes mellitus Vanderbilt University Medical Center Terminated No outcome recorded
Phase 1/2 NCT04752774 Apr 2021 → Mar 2029 expected Ipsen Recruiting No outcome recorded
Phase 1/2 NCT05127018 Nov 2019 → Aug 2020 Peking University Completed No outcome recorded
Phase 1/2 NCT04281095 Nov 2019 → Apr 2020 ATGC Co., Ltd. Completed No outcome recorded
Phase 1/2 NCT03922139 Oct 2019 → Dec 2021 compartment syndrome University of Wisconsin, Madison Terminated No outcome recorded
Phase 1/2 NCT03066635 Apr 2017 → Sep 2019 cluster headache syndrome Norwegian University of Science and Technology Completed No outcome recorded
Phase 1/2 NCT02674269 Oct 2016 overactive bladder UroGen Pharma Ltd. Withdrawn No outcome recorded
Phase 2158 trials
Phase 2 NCT07489430 Jul 2026 → Jun 2028 expected benign essential blepharospasm University of Pennsylvania Not yet recruiting No outcome recorded
Phase 2 NCT07553065 Jul 2026 → Sep 2027 expected overactive bladder Vensica Therapeutics Ltd. Not yet recruiting No outcome recorded
Phase 2 NCT07537855 Jun 2026 → Jun 2028 expected erectile dysfunction Northwestern University Not yet recruiting No outcome recorded
Phase 2 NCT07399782 Apr → Sep 2026 expected obstructive sleep apnea syndrome Hospital Felicio Rocho Not yet recruiting No outcome recorded
Phase 2 NCT07486830 Feb → Dec 2026 expected vulvodynia Center for Vulvovaginal Disorders Recruiting No outcome recorded
Phase 2 NCT07399860 Feb 2026 → Jan 2027 expected hemorrhoid Lomonosov Moscow State University Medical Research and Educational Center Recruiting No outcome recorded
Phase 2 NCT07335367 Jan → Aug 2026 overdue androgenetic alopecia Nanfang Hospital, Southern Medical University Recruiting No outcome recorded
Phase 2 NCT06530524 Oct 2024 → Oct 2026 expected head and neck cancer Sir Mortimer B. Davis - Jewish General Hospital Not yet recruiting No outcome recorded
Phase 2 NCT06293300 Sep 2024 → Sep 2026 expected traumatic brain injury University of Miami Recruiting No outcome recorded
Phase 2 NCT05606757 May 2024 → Apr 2025 abdominal wall malformation AbbVie Withdrawn No outcome recorded
Show all 158 trials opens the full record — a long page
Phase 2/324 trials
Phase 2/3 NCT06902805 Dec 2025 → May 2027 expected osteoarthritis, hand Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
Phase 2/3 NCT06755099 Jan 2025 → Aug 2026 overdue sexual disorder Assiut University Not yet recruiting No outcome recorded
Phase 2/3 NCT06721520 Dec 2024 → Dec 2027 expected achalasia, dyskinesia of esophagus, esophageal cancer, functional gastric disease The Cleveland Clinic Recruiting No outcome recorded
Phase 2/3 NCT06583590 Aug 2024 → Aug 2025 overdue erectile dysfunction Aswan University Hospital Recruiting No outcome recorded
Phase 2/3 NCT06851598 Jul 2024 → Feb 2025 overdue premature ejaculation Abdallah Mohamed Abdallah Mohamed Elgendy Active not recruiting No outcome recorded
Phase 2/3 NCT04695600 Aug 2023 → Aug 2027 expected disorder of pharynx, dysphagia lusoria, retrograde cricopharyngeus dysfunction All India Institute of Medical Sciences Recruiting No outcome recorded
Phase 2/3 NCT05878951 Jul 2023 → Sep 2026 expected overactive bladder Northwestern University Recruiting No outcome recorded
Phase 2/3 NCT05367271 Aug 2022 → Sep 2024 plantar fasciitis Western Institute for Veterans Research Completed No outcome recorded
Phase 2/3 NCT05651256 Mar 2021 temporomandibular joint disorder University of Salamanca Completed No outcome recorded
Phase 2/3 NCT04277247 Jan 2021 → Dec 2022 Parkinson disease, dystonic disorder University of Calgary Unknown No outcome recorded
Phase 3185 trials
Phase 3 NCT05698979 Jan 2027 → Feb 2028 expected Raynaud disease, thromboangiitis obliterans University Hospital, Toulouse Not yet recruiting No outcome recorded
Phase 3 NCT07470164 Jan 2027 → Jan 2030 expected esotropia Jaeb Center for Health Research Not yet recruiting No outcome recorded
Phase 3 NCT06995287 Feb 2026 → Jun 2028 expected chronic pain syndrome, primary dysmenorrhea Nantes University Hospital Recruiting No outcome recorded
Phase 3 NCT07210463 Oct 2025 → Jan 2027 expected Merz Aesthetics GmbH Recruiting No outcome recorded
Phase 3 NCT07122193 Aug 2025 → Oct 2026 expected Merz North America, Inc. Active not recruiting No outcome recorded
Phase 3 NCT07018700 Aug 2025 → Mar 2027 expected migraine disorder Merz Therapeutics GmbH Recruiting No outcome recorded
Phase 3 NCT07018713 Aug 2025 → Oct 2027 expected migraine disorder Merz Therapeutics GmbH Recruiting No outcome recorded
Phase 3 NCT07013240 Jul 2025 → Feb 2027 expected University Hospital, Bordeaux Not yet recruiting No outcome recorded
Phase 3 NCT06794866 Jan 2025 → Apr 2026 AbbVie Completed No outcome recorded
Phase 3 NCT06499324 Jan 2025 → Aug 2028 expected Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
Show all 185 trials opens the full record — a long page
Phase 4124 trials
Phase 4 NCT07295288 Jul 2026 → Jun 2027 expected cranial nerve neuropathy Vanderbilt University Medical Center Not yet recruiting No outcome recorded
Phase 4 NCT07646886 Jul 2026 → Jun 2027 expected Peking University Not yet recruiting No outcome recorded
Phase 4 NCT05393921 Jun 2026 → Jul 2027 benign prostatic hyperplasia, overactive bladder University Hospitals Cleveland Medical Center Withdrawn No outcome recorded
Phase 4 NCT07220382 Nov 2025 → Dec 2027 expected abdominal wall malformation, compartment syndrome The Cleveland Clinic Recruiting No outcome recorded
Phase 4 NCT07082972 Sep 2025 → Sep 2026 expected myofascial pain syndrome Istanbul University Recruiting No outcome recorded
Phase 4 NCT06195241 Feb 2025 → Mar 2027 expected benign essential blepharospasm, facial spasm Montefiore Medical Center Recruiting No outcome recorded
Phase 4 NCT06783621 Jan 2025 → Mar 2026 AbbVie Completed No outcome recorded
Phase 4 NCT06237465 Jan → Jun 2025 hidradenitis suppurativa Yale University Withdrawn No outcome recorded
Phase 4 NCT06556030 Jan 2025 → Jun 2026 overdue salivary substance, Clostridium botulinum type Instituto de Investigación Hospital Universitario La Paz Not yet recruiting No outcome recorded
Phase 4 NCT06356025 Sep 2024 → Dec 2025 overdue retrograde cricopharyngeus dysfunction AZ Delta Active not recruiting No outcome recorded
Show all 124 trials opens the full record — a long page
Phase not applicable101 trials
NCT07666347 Jun → Dec 2026 expected osteoarthritis, knee Tanta University Recruiting No outcome recorded
NCT07665528 Jun → Sep 2026 expected ulcer of anus and rectum Islamabad Medical and Dental College Recruiting No outcome recorded
NCT07626983 May → Dec 2026 expected chronic pain syndrome, nervous system injury, neuroma Ukrainian Society of Regional Anesthesia and Pain Therapy Not yet recruiting No outcome recorded
NCT07624877 May 2026 overdue chronic pain syndrome, neuroma Ukrainian Society of Regional Anesthesia and Pain Therapy Not yet recruiting No outcome recorded
NCT07535723 Apr → Oct 2026 expected migraine disorder Beni-Suef University Not yet recruiting No outcome recorded
NCT07568314 Mar → Jun 2026 overdue ulcer of anus and rectum Islamabad Medical and Dental College Recruiting No outcome recorded
NCT07431944 Feb 2026 overdue Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) Not yet recruiting No outcome recorded
NCT07673471 Feb → May 2026 bruxism, odontoclasia Biruni University Completed No outcome recorded
NCT07452510 Jan → Apr 2026 bruxism, masticatory muscles, hypertrophy of, parasomnia, sleep bruxism type, temporomandibular joint disorder Recep Tayyip Erdogan University Completed No outcome recorded
NCT07473635 Jan → Jul 2026 overdue complex regional pain syndrome type 1, complex regional pain syndrome type 2 Bo Biering-Soerensen Recruiting No outcome recorded
Also used as a comparator or background therapy in 278 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 010 trials
Phase 0 NCT06811142 Comparator Jan 2025 → Feb 2027 expected stroke disorder Mexican Social Security Institute Active not recruiting No outcome recorded
Phase 0 NCT06793683 Comparator Jul 2024 → Apr 2028 expected spinal cord injury University of Washington Enrolling by invitation No outcome recorded
Phase 0 NCT06013644 Comparator Jun 2023 → Feb 2024 myofascial pain syndrome Cairo University Unknown No outcome recorded
Phase 0 NCT05807412 Comparator May 2023 → Feb 2024 Lupo Center for Aesthetic and General Dermatology Completed No outcome recorded
Phase 0 NCT05305768 Comparator May 2022 → Feb 2023 Clinical Testing of Beverly Hills Unknown No outcome recorded
Phase 119 trials
Phase 1 NCT06604832 Comparator Sep 2024 → Aug 2025 Kalpna Kay Durairaj, MD, FACS Completed No outcome recorded
Phase 1 NCT07361900 Comparator Mar 2024 → Jul 2025 parasomnia, sleep bruxism type Delta University for Science and Technology Completed No outcome recorded
Phase 1 NCT05956509 Comparator Jan → Jun 2024 AbbVie Terminated No outcome recorded
Phase 1 NCT06212960 Comparator Nov 2023 → Feb 2024 Daewoong Pharmaceutical Co. LTD. Completed No outcome recorded
Phase 1 NCT07292025 Comparator Jun 2023 → Apr 2024 diplegia of upper limb Jetema Co., Ltd. Completed No outcome recorded
Phase 1/210 trials
Phase 1/2 NCT06824324 Comparator Mar → Nov 2024 myofascial pain syndrome Yassir R. Al-khannaq Completed No outcome recorded
Phase 1/2 NCT06199336 Comparator Jan → Sep 2024 JHM BioPharma (Tonghua) Co. , Ltd. Completed No outcome recorded
Phase 1/2 NCT05892770 Background Aug 2023 → Dec 2025 overdue spasmodic dystonia University of Florida Active not recruiting No outcome recorded
Phase 1/2 NCT04585620 Comparator Sep 2022 → Dec 2023 chronic pain syndrome, neuropathy, painful Allan Vestergaard Danielsen, MD Unknown No outcome recorded
Phase 1/2 NCT05743634 Comparator Mar 2022 → Feb 2023 Chongqing Claruvis Pharmaceutical Co., Ltd. Completed No outcome recorded
Phase 251 trials
Phase 2 NCT06465056 Comparator Jan 2024 → Jan 2025 ptosis University of Sao Paulo Unknown No outcome recorded
Phase 2 NCT06003049 Comparator Oct 2023 → Apr 2024 chronic obstructive pulmonary disease RMW Testing Completed No outcome recorded
Phase 2 NCT05720065 Comparator Sep 2023 → Jun 2025 overdue temporomandibular joint disorder Karolinska Institutet Recruiting No outcome recorded
Phase 2 NCT05623111 Comparator Aug 2023 → May 2027 expected diabetic neuropathy Rigshospitalet, Denmark Recruiting No outcome recorded
Phase 2 NCT06034288 Comparator May 2023 → Jun 2024 overactive bladder Walter Reed National Military Medical Center Unknown No outcome recorded
Phase 2/311 trials
Phase 2/3 NCT06676475 Comparator Dec 2024 → Feb 2025 overdue myofascial pain syndrome Misr University for Science and Technology Not yet recruiting No outcome recorded
Phase 2/3 NCT06783114 Comparator Sep 2024 → Sep 2026 expected Chongqing Claruvis Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 2/3 NCT06296082 Comparator Sep 2024 → Dec 2026 expected stroke disorder University of Antwerp Recruiting No outcome recorded
Phase 2/3 NCT06814535 Comparator Jun 2024 → Mar 2025 overdue myofascial pain syndrome Cairo University Active not recruiting No outcome recorded
Phase 2/3 NCT04172558 Comparator Mar 2019 → Oct 2022 erectile dysfunction Benha University Unknown No outcome recorded
Phase 363 trials
Phase 3 NCT07013279 Comparator Jul → Dec 2025 overdue Daewoong Pharmaceutical Co. LTD. Not yet recruiting No outcome recorded
Phase 3 NCT07040813 Comparator Jun 2025 → Jan 2029 expected migraine disorder Oslo University Hospital Recruiting No outcome recorded
Phase 3 NCT06941636 Comparator May 2025 → Dec 2026 expected temporomandibular joint disorder Region Stockholm Recruiting No outcome recorded
Phase 3 NCT06937944 Comparator Apr → Dec 2025 overdue JHM BioPharma (Tonghua) Co. , Ltd. Recruiting No outcome recorded
Phase 3 NCT06729840 Comparator Dec 2024 → Apr 2025 overdue keloid formation Sohag University Recruiting No outcome recorded
Phase 473 trials
Phase 4 NCT06448676 Comparator Feb 2026 → Jan 2027 expected Academic Medical Center - University of Amsterdam Recruiting No outcome recorded
Phase 4 NCT06886750 Comparator Mar 2025 → Mar 2027 expected cervical dystonia Western University, Canada Not yet recruiting No outcome recorded
Phase 4 NCT07586072 Comparator Aug 2024 → Aug 2025 bruxism, myofascial pain syndrome, temporomandibular joint disorder Recep Tayyip Erdogan University Completed No outcome recorded
Phase 4 NCT06724250 Comparator Aug 2023 → Aug 2024 outlet dysfunction constipation Mansoura University Completed No outcome recorded
Phase 4 NCT05806164 Comparator Jun 2023 → Aug 2026 overdue overactive bladder Women and Infants Hospital of Rhode Island Active not recruiting No outcome recorded
Phase not applicable41 trials
NCT05765071 Comparator Jul 2025 → Jun 2028 expected compartment syndrome University of Calgary Recruiting No outcome recorded
NCT07184307 Comparator Apr 2025 → Apr 2026 overdue overactive bladder Benha University Recruiting No outcome recorded
NCT07715331 Comparator Jan 2025 → Feb 2026 gingival disorder Al-Azhar University Completed No outcome recorded
NCT07360483 Comparator Jan → May 2025 Cairo University Completed No outcome recorded
NCT06684249 Comparator Nov 2024 → May 2025 overdue migraine disorder Zagazig University Recruiting No outcome recorded

Press releases naming this drug 54 releases

DateIssuerRelease
2026-08-04 AbbVie Allergan Aesthetics Announces U.S. FDA Acceptance of Supplemental Biologics License Application for BOTOX® Cosmetic for Masseter Muscle Prominence abbvie.com
2026-07-17 AbbVie Allergan Aesthetics receives approval for Boey® (trenibotulinumtoxinE), for use in Europe: the first and only rapid-onset, short-duration neurotoxin for the temporary improvement of frown lines in adult patients abbvie.com
2026-07-09 Ipsen Dysport® is the first botulinum toxin to achieve positive topline Phase III results in both episodic and chronic migraine. ipsen.com
2026-06-24 AbbVie BOTOX® Cosmetic (onabotulinumtoxinA) Introduces The Confidence Collective's Entrepreneur Class of 2026 abbvie.com
2026-06-23 AbbVie Allergan Aesthetics receives approval for Boey® (trenibotulinumtoxinE) in Canada, the first and only rapid-onset, short-duration neurotoxin for the temporary improvement of frown lines in adult patients abbvie.com
2026-05-19 Ipsen Ipsen announces late-breaking data from first head-to-head study comparing Dysport® and Botox® in adults with upper limb spasticity ipsen.com
2026-04-08 AbbVie BOTOX® Cosmetic (onabotulinumtoxinA) Empowers Women Entrepreneurs Through "The Confidence Collective" for Fourth Year abbvie.com
2025-10-29 AbbVie The One & Only BOTOX® Cosmetic (onabotulinumtoxinA) Day Returns November 19 with the Biggest Celebration of the Year abbvie.com
2025-10-06 AbbVie AbbVie Announces Positive Topline Results from Phase 2 ELATE Trial Evaluating OnabotulinumtoxinA (BOTOX®) for the Treatment of Upper Limb Essential Tremor abbvie.com
2025-09-09 AbbVie BOTOX® Cosmetic (onabotulinumtoxinA) Unveils "The One & Only" Campaign Featuring Real People and Their Distinctive Stories abbvie.com
2024-11-07 AbbVie Allergan Aesthetics Celebrates Annual BOTOX® Cosmetic (onabotulinumtoxinA) Day abbvie.com
2024-10-18 AbbVie BOTOX® Cosmetic (onabotulinumtoxinA) Receives FDA Approval for Moderate to Severe Vertical Bands Connecting the Jaw and Neck (Platysma Bands) abbvie.com

Evidence & citations 125 cited values

Every value below carries the sentence it was read from. 1,032 sources stand behind the page.

FieldValueCited text
Known as Botulinum toxin type A “Since its introduction in the 1970s for the treatment of strabismus, blepharospasm, and focal dystonia, botulinum toxin type A (BTX-A) has been widely used in the treatment of...” NCT03555916
345

“Another recent evidence suggests an enhanced sensitization of central pain processing in patients with RLS. This had led to consider the botulinum toxin type A (BNT) as an...” NCT00949806

“The SILENCE-NEUROMA Trial is a multicenter, randomized, double-blind, active-controlled study designed to compare the efficacy and safety of botulinum toxin type A versus local...” NCT07431944

“The safety and efficacy of Mentor Purified Toxin, Botulinum Toxin Type A, Purified Neurotoxin, injected intramuscularly into the neck, is being evaluated as a treatment for...” NCT00549341

Botulinum toxin type A (BoNT-A), a peripheral neuromodulator, has been proposed as a potential therapeutic alternative by inducing chemodenervation and muscle volume reduction,...” NCT07399782

“The main objective is to evaluate the analgesic efficacy of botulinum toxin type A in refractory chronic proctalgia one month after a bilateral injection of 50 units of Botox ®...” NCT01331356

“In the Egyptian market two commercial forms are available; botulinum toxin type A (Botox 100 IU/vial; Coolock, Dublin, Ireland), and abobotulinumtoxin A (Dysport 500 U/vial;...” NCT03920449

“Botox containing Botulinum toxin type A is a purified substance, derived from a bacterium that block muscular nerve signals temporarily preventing the muscular contraction and...” NCT05162300

Botulinum toxin type A (BTX-A; Botox, Allergan, Inc., Irvine, CA, USA) was administered through intramuscular injection into the masseter and temporalis muscles during a single...” NCT07361900

Botulinum toxin type A (BoNT-A) is widely used to treat muscle hyperactivity, based on its ability to inhibit synaptic exocytosis and, therefore, to disable neural transmission.” NCT05411900

“The aim was to compare the efficacy of intraarticular Botulinum toxin type A (BoNT-A) and intraarticular hyaluronate plus rehabilitation exercise in patients with ankle OA.” PMID 24502534 Feb 2014

Botulinum toxin type A (BTX-A) has been reported to have analgesic effects independent of its action on muscle tone, possibly by acting on neurogenic inflammation.” PMID 18546285 Sep 2008

Botulinum Toxin Type A (AGN-151607) for the Prevention of Post-operative Atrial Fibrillation in Adult Participants Undergoing Open-chest Cardiac Surgery (NOVA)” NCT03779841

“Botulinum toxin type-A (BoNT-A) is often used for refractory cases unresponsive to conservative therapies; however, its biological mechanisms remain unclear.” PMID 42062988 Apr 2026

“OBJECTIVE: To compare the effects of 2 different injection sites of low doses of botulinum toxin type A with steroid in treating lateral epicondylalgia.” PMID 27666156 Sep 2016

“Treatment plan was established by utilizing thirty units of Botulinum toxin type (A) which was injected into masseter and sometimes temporalis muscle.” NCT06824324

botulinum toxin type A (BTA) is recommended for the treatment of migraine, myofascial pain syndrome, and neuropathic pain accompanied by allodynia.” NCT06470581

“The ideal dosage for botulinum toxin type A (BoNT-A), a sphincter-preserving substitute for lateral internal sphincterotomy, is still unknown.” NCT07543315

Botulinum toxin type A (BTXA) injection is a well established, clinically effective and safe treatment for muscle spasticity in CP (2;19;20).” NCT01437644

“The purpose of this study is to determine the effectiveness of treatment of idiopathic clubfoot utilizing Botulinum Toxin Type A (Botox).” NCT00474032

“Local ultrasound-guided bilateral injection of botulinum toxin type A in parotid (35 UI/gland) and submandibular (15 UI/gland) glands.” NCT01551940

Botulinum toxin type A is a neurotoxin produced by the bacterium Clostridium botulinum which causes a flaccid muscle paralysis.” PMID 17177750 Sep 2006

“Non-randomised studies assessing intrarectal botulinum toxin type A (BoNTA) injections for faecal incontinence are promising.” PMID 38128556 Dec 2023

Botulinum toxin type A was injected into the bulbospongiosus muscle and glans penis according to a standerdized protocol.” NCT07426640

botulinum toxin type A (onabotulinumtoxinA; onabotA) injections to induce temporary paralysis in the glabellar muscles” PMID 36849797 Feb 2023

Botulinum toxin type A (BOTOX®) injections will performed on an outpatient basis by cystoscopy under local anesthesia.” NCT04819360

“BOTOX®, a botulinum toxin type A produced from Clostridium botulinum, blocks certain chemicals that cause spasticity.” NCT00565201

“Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)” NCT06293300

“Partial Blocks of Rectus Femoris and Soleus With Botulinum Toxin Type A (Xeomin®) to Improve Gait in Hemiparesis” NCT03119948

“different doses of botulinum toxin type A (abobotulinumtoxin A) for the treatment of upper anterior gummy smile” NCT03284047

“Patients will receive a total of 20 units of botulinum toxin type A (Botox) injected into each masseter muscle.” NCT07082972

“Treatment of hypertrophic scars with intralesional botulinum toxin type A injections: a preliminary report.” PMID 19357910 Apr 2009

“100 MU of botulinum toxin type A (BOTOX® - Allergan Inc. - Dublin - Ireland) were diluted in 2ml of saline.” NCT05620316

“Each patient received six randomized injections of botulinum toxin type A (Botox® Allergan).” NCT00628472

“the patient will receive Botulinum toxin type A followed by surgical closure of cleft lip” NCT07137234

“OnabotulinumtoxinA (botulinum toxin Type A) 200U injected into the prostate on Day 1.” NCT00894517

Botulinum toxin type A is a neurotoxin used to reduce excessive muscle contraction.” NCT06676475

“A single injection of 60 units of botulinum toxin type A or normal saline placebo.” PMID 16330790 Dec 2005

Botulinum Toxin Type A in Treatment of Cranial Allodynia in Patients With Headache” NCT01357798

Botulinum toxin type A is a neurotoxin derived from Clostridium botulinum culture.” NCT07013240

botulinum toxin type A (BTX-A) treatment is an easy and fast outpatient procedure” NCT04820543

“Each vial of BOTOX (Botulinum Toxin Type A) purified neurotoxin complex” NCT02097121

botulinum toxin type A (BT-A) have also been demonstrated to reduce HSP” NCT01473277

“Will include 15 patients will injected with botulinum toxin type ANCT06729840

Botulinum Toxin Type a (Dysport®, Abobotulinum Toxin A) Injection” NCT02917967

“Micro-Botox, is a highly diluted Botulinum toxin type ANCT06544993

Botulinum toxin Type A topical liniment (ANT-1207).” NCT02479139

“Botulinum toxin type-A (Onabotulinum toxin type-A)” NCT04940143

“Intragastric injection of Botulinum toxin type ANCT04274608

“Botulinum Toxin (Type A) injection (10 U/Kg)” NCT00474032

Botulinum Toxin Type A - OnabotulinumtoxinA” NCT00661089

Botulinum Toxin Type A (Botox) and Placebo” NCT00152347

“BOTOX Cosmetic™ (Botulinum Toxin Type A)” NCT00250952

“Intervention-Botulinum Toxin Type ANCT01905137

“Biological: Botulinum Toxin, Type A” NCT01358695

“Meditoxin (Botulinum toxin type A)” NCT03452345

“Biological: Botulinum Toxin Type ANCT01358695

Botulinum toxin type A(Botox®)” NCT01791920

“Botox (Botulinum toxin type A)” NCT03908008

botulinum toxin Type ANCT02230956

Botulinum toxin type ANCT00825097

NCT00288509

NCT00444886

NCT01405482

NCT05324839

NCT03812965

NCT06356025

NCT03747900

NCT00876447

NCT03346252

NCT07673471

NCT07385742

NCT02668497

NCT02773641

NCT00819065

NCT02493946

NCT01271452

NCT01603615

NCT01915459

NCT00989768

NCT01821573

NCT04922983

NCT00455637

NCT01308060

NCT01518257

NCT00575016

NCT03326856

NCT00989209

NCT06282679

NCT06804993

NCT00408785

NCT03102762

NCT01603641

NCT04073303

NCT00915525

NCT01391312

NCT00258609

NCT05194488

NCT01391299

NCT02403219

NCT00076687

NCT01603628

NCT01429402

NCT01205451

NCT03894748

NCT00004416

NCT06349733

NCT05309564

NCT00564681

NCT02051933

NCT07295288

NCT04186442

NCT04467450

NCT00168402

NCT01004042

NCT00732680

NCT01603602

NCT00168428

NCT00168441

NCT01945684

NCT01791881

NCT02586142

NCT00850421

NCT00447772

NCT05720065

NCT00447876

NCT00168480

NCT06207955

NCT00439140

NCT07526870

NCT07561580

NCT05112081

NCT00816517

NCT07331844

NCT02259075

NCT03799484

NCT04069897

NCT02969356

NCT03198702

NCT01564979

NCT03654066

NCT02002962

NCT01064518

NCT01911377

NCT02577185

NCT01682148

NCT01575054

NCT00770406

NCT03381261

NCT05604729

NCT02886988

NCT03839693

NCT07626983

NCT01313312

NCT03655691

NCT05330078

NCT07399860

NCT06410859

NCT03508882

NCT01249404

NCT07586072

NCT01249417

NCT01272414

NCT07070817

NCT00149240

NCT02292472

NCT01691651

NCT01787344

NCT01384214

NCT02584686

NCT02280083

NCT03355963

NCT01776606

NCT02858219

NCT02147561

NCT03891121

NCT04502264

NCT00930709

NCT01045694

NCT00179114

NCT00060957

NCT03549975

NCT02660138

NCT02662530

NCT03294382

NCT02469948

NCT00908050

NCT03459092

NCT02247193

NCT00282958

NCT03641950

NCT01237977

NCT00134810

NCT07076355

NCT02351544

NCT02512536

NCT02334436

NCT01818076

NCT00216411

NCT01529203

NCT03726788

NCT01357980

NCT04695600

NCT04917731

NCT01432782

NCT02810015

NCT07236632

NCT00432341

NCT02786407

NCT05072821

NCT01357798

NCT04426123

NCT03054480

NCT02334423

NCT03903653

NCT00549783

NCT06094309

NCT02749591

NCT00434863

NCT03193359

NCT01662492

NCT04171258

NCT00210444

NCT03944876

NCT03302871

NCT05892770

NCT04938102

NCT00234546

NCT03717987

NCT03306940

NCT01251211

NCT01495962

NCT04939909

NCT00812838

NCT01274611

NCT04277247

NCT03238898

NCT01814670

NCT01940991

NCT03193346

NCT01591746

NCT00822523

NCT03203174

NCT01460355

NCT00578097

NCT02557737

NCT01251380

NCT05887479

NCT06974617

NCT04985916

NCT02035397

NCT03079557

NCT06213662

NCT04750291

NCT04485780

NCT02291380

NCT02460107

NCT01282541

NCT04857671

NCT04595045

NCT00968942

NCT00464373

NCT02236312

NCT03369990

NCT02010775

NCT00451191

NCT01256021

NCT01018485

NCT01336439

NCT00432055

NCT05964257

NCT00822926

NCT07335367

NCT02965976

NCT00247559

NCT00971620

NCT07360483

NCT03236012

NCT03223298

NCT02353871

NCT02400619

NCT00477802

NCT00945295

NCT00301665

NCT07568314

NCT01107392

NCT00968825

NCT01297634

NCT06237465

NCT00276315

NCT01129583

NCT04965311

NCT02498769

NCT00999869

NCT01177358

NCT07665528

NCT04443244

NCT01259557

NCT04281095

NCT06465056

NCT00856414

NCT02565732

NCT02660359

NCT05651256

NCT06128616

NCT03912805

NCT01276015

NCT04944953

NCT01579500

NCT06196606

NCT06437912

NCT03569098

NCT07666347

NCT01797094

NCT01797081

NCT07645456

NCT00279903

NCT02580370

NCT06328556

NCT03704155

NCT00336349

NCT07715331

NCT05517538

NCT02195687

NCT02601287

NCT06047444

NCT00528541

NCT00211679

NCT03317574

NCT01753310

NCT03331913

NCT03472261

NCT00651729

NCT00004480

NCT06047457

NCT00651690

NCT00178945

NCT00246142

NCT01753336

NCT00211718

NCT00246155

NCT02551848

NCT02444351

NCT00257660

NCT05863286

NCT02829281

Known as 25 units botox ClinicalTrials.gov intervention name — accepted as the source's own label NCT06851598
Known as 93094EC “Product name: Onabotulinum toxin A (Botox A, Allergan), 50 unit vials Product code: 93094ECNCT04383912
Known as ABO “Drug: AbobotulinumtoxinA (ABO)” NCT01732809
Known as abo-BoNT-A “AIM: To define optimal (safe and efficacious) doses of abobotulinumtoxinA (aboBoNT-A) for the treatment of PVD associated with hypertonic pelvic floor muscle dysfunction and to...” PMID 39953376 Apr 2025
4

“OBJECTIVE: To assess changes in walking velocity (WV), step length, and cadence under different test conditions after repeated treatment with abobotulinumtoxinA (aboBoNT-A;...” PMID 32741133 Sep 2020

“Longer waning time is associated with abobotulinumtoxinA (abo-BoNT-A) as compared to onabotulinumtoxinA (ona-BoNT-A)/incobotulinumtoxinA (inco-BoNT-A) formulations.” PMID 37205243 Mar 2023

“OBJECTIVE: To assess the efficacy and safety of abobotulinumtoxinA (aboBoNT-A) for NDOI.” PMID 35400537 Apr 2022

NCT04936542

Known as abobotulinumtoxinA “The most commonly used subtype is toxin A commercially found as BOTOX (onabotulinumtoxinA, Allergan, approved by FDA in 1989), Dysport (abobotulinumtoxinA, Medicis, approved by...” NCT03186001
49

“In the absence of scientific evidence between the efficacy of onabotulinumtoxin A and abobotulinumtoxin A, physician will be free to choose between these two BoNT formulation...” NCT05874154

“AIM: To define optimal (safe and efficacious) doses of abobotulinumtoxinA (aboBoNT-A) for the treatment of PVD associated with hypertonic pelvic floor muscle dysfunction and to...” PMID 39953376 Apr 2025

“This study aims to evaluate the efficacy of single event multi level chemoneurolysis with the abobotulinumtoxin A drug, Dysport®, on walking energy expenditure and gait in...” NCT03469999

“OBJECTIVE: To assess changes in walking velocity (WV), step length, and cadence under different test conditions after repeated treatment with abobotulinumtoxinA (aboBoNT-A;...” PMID 32741133 Sep 2020

“In the Egyptian market two commercial forms are available; botulinum toxin type A (Botox 100 IU/vial; Coolock, Dublin, Ireland), and abobotulinumtoxin A (Dysport 500 U/vial;...” NCT03920449

“Lack of head-to-head comparative safety and efficacy data for abobotulinumtoxinA (aboBoNT-A) and onabotulinumtoxinA (onaBoNT-A) represented an important gap for informed...” PMID 42159955 May 2026

“Longer waning time is associated with abobotulinumtoxinA (abo-BoNT-A) as compared to onabotulinumtoxinA (ona-BoNT-A)/incobotulinumtoxinA (inco-BoNT-A) formulations.” PMID 37205243 Mar 2023

“The ONTIME study investigated whether early post-stroke abobotulinumtoxinA injection delays appearance or progression of upper limb spasticity (ULS) symptoms.” PMID 29933562 Jun 2018

“Their study designs involved repeat intramuscular injections of abobotulinumtoxinA (Dysport®), and efficacy endpoints were collected accordingly.” PMID 29781237 May 2018

“different doses of botulinum toxin type A (abobotulinumtoxin A) for the treatment of upper anterior gummy smile” NCT03284047

AbobotulinumtoxinA solution for injection is a ready-to-use liquid formulation of abobotulinumtoxinA.” PMID 27653448 Sep 2016

“Two Botulinum Type A Exotoxins (Onabotulinum Toxin A and Abobotulinum Toxin A)” NCT01529788

“The Effect of Abobotulinum Toxin A on the Symptoms of Raynaud's Phenomenon” NCT03639766

“75 units of abobotulinumtoxinA in FCR and FCU and 25 units in ECR and ECU” NCT02909907

“Botulinum Toxin Type a (Dysport®, Abobotulinum Toxin A) Injection” NCT02917967

“1 dose of 60 units of abobotulinum toxin A (ABoNT/A);” PMID 40434770 Jul 2025

AbobotulinumtoxinA: 50 (Speywood) units” NCT06448676

AbobotulinumtoxinA (DysportRU®)” NCT01333397

abobotulinumtoxinA (Dysport®)” NCT04970407

AbobotulinumtoxinA (Dysport®)” NCT02106351

AbobotulinumtoxinA (Dysport®)” NCT03663101

AbobotulinumtoxinA (Dysport®)” NCT00234507

AbobotulinumtoxinA (Dysport®)” NCT02450526

NCT01921270

NCT03048383

NCT04886167

NCT03960957

NCT03928496

NCT03585569

NCT02221648

NCT05466539

NCT02907268

NCT03687736

NCT03136341

NCT03639766

NCT06946160

NCT03935295

NCT00950664

NCT03186001

NCT03736928

NCT06250543

NCT01732809

NCT07452510

NCT04756882

NCT05167864

NCT04470401

NCT03978234

NCT02187679

NCT04080882

Known as AbobotulinumtoxinA (Azzalure) “AbobotulinumtoxinA (Azzalure®)” NCT01333397
Known as AbobotulinumtoxinA (Dysport) “AbobotulinumtoxinA (Dysport®)” NCT00234507
15

“AbobotulinumtoxinA (Dysport®)” NCT03663101

“AbobotulinumtoxinA (Dysport®)” NCT02450526

“AbobotulinumtoxinA (Dysport®)” NCT00257660

“AbobotulinumtoxinA (Dysport®)” NCT03569098

“AbobotulinumtoxinA (Dysport®)” NCT01251367

“AbobotulinumtoxinA (Dysport®)” NCT00210444

“AbobotulinumtoxinA (Dysport®)” NCT02321436

“AbobotulinumtoxinA (Dysport®)” NCT02106351

“AbobotulinumtoxinA (Dysport®)” NCT01249417

“AbobotulinumtoxinA (Dysport®)” NCT01313312

“AbobotulinumtoxinA (Dysport®)” NCT01313299

“AbobotulinumtoxinA (Dysport®)” NCT01261611

“abobotulinumtoxinA (Dysport®)” NCT04970407

“AbobotulinumtoxinA (Dysport®)” NCT03598777

“AbobotulinumtoxinA (Dysport®)” NCT00455637

Known as AbobotulinumtoxinA (DysportRU) “AbobotulinumtoxinA (DysportRU®)” NCT01333397
1

“AbobotulinumtoxinA (DysportRU®)” NCT01261611

Known as aboboutlinum toxin A “This prospective double-blind randomized control trial seeks to compare a single formulation of BoNT, aboboutlinum toxin A (Dysport), to a placebo saline group, studying the...” NCT03639766
Known as ABoNT/A “1 dose of 60 units of abobotulinum toxin A (ABoNT/A);” PMID 40434770 Jul 2025
Known as AGN 151607 “Botulinum Toxin Type A (AGN-151607) for the Prevention of Post-operative Atrial Fibrillation in Adult Participants Undergoing Open-chest Cardiac Surgery (NOVA)” NCT03779841
1

NCT03779841

Known as ANT-1207 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02479139
2

NCT01358695

NCT01293552

Known as ANT-1401 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01809964
1

NCT01951742

Known as ANT-1403 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01799824
Known as Azzalure “Botulinum Toxin Type A (Azzalure)” NCT01529203
Known as Bao Tuo Shi “Botulinum Toxin A type for injection (BOTOX®, Bao Tuo Shi®)” NCT05380154
Known as BNT “Recently, botulinum toxin type A (BNT) has been reported to relief RLS in patients with severe symptoms but this was not confirmed by other anecdotal reports.” NCT00949806
Known as Bocouture “IncobotulinumtoxinA (NT 201, Xeomin/Xeomeen/Bocouture, Merz Pharmaceuticals GmbH, Frankfurt, Germany) is a 150-kDa botulinum toxin type A free of complexing proteins.” PMID 23379292 Feb 2013
1

“NT 201, also known as IncobotulinumtoxinA (Xeomin®/Bocouture®), is a Botulinum toxin type A preparation free of complexing proteins (150 kiloDalton).” NCT00777803

Known as BoNT “Onabotulinumtoxin A (BoNT)” NCT02600715
Known as BoNT A1 = Dysport BoNT A1 = DysportNCT00959907
Known as BoNT A2 = Botox BoNT A2 = BotoxNCT00959907
Known as BoNT-A “AIM: To assess the effect of single botulinum neurotoxin A (BoNT-A) injections into the calf muscles on the gross energy cost of walking in children with cerebral palsy (CP)...” PMID 39058740 Jul 2024
44

“Although numerous articles were published on the Botulinum Toxin A (BoNTA) injection in the management of MPS, but there were diverse clinical results in the literature...” NCT06824324

“Botulinum toxin type A (BoNT-A), a peripheral neuromodulator, has been proposed as a potential therapeutic alternative by inducing chemodenervation and muscle volume reduction,...” NCT07399782

“Botulinum Toxin type A The intervention with BoNT-A (Dysport®, Ipsen Biopharmaceutical, USA) was performed in the gastrocnemius and soleus muscles, bilaterally for diplegic...” NCT03704155

“Participants with a Modified Ashworth Scale (MAS) score of 1+ or above received BoNT-A (Dysport) 500 U or placebo to one or more wrist and elbow mover muscles, plus...” PMID 22371239 Feb 2012

“OBJECTIVE: To investigate whether extracorporeal shock wave therapy (ESWT) is noninferior to botulinum toxin type A (BoNT-A) for the treatment of poststroke upper limb spasticity.” PMID 30392753 Jul 2018

“Botulinum Neurotoxin-A (BoNT-A), when applied intramuscularly, inhibits presynaptic acetylcholine (Ach) release by preventing the fusion of Ach vesicles with the plasma membrane.” NCT06583343

“The aim was to compare the efficacy of intraarticular Botulinum toxin type A (BoNT-A) and intraarticular hyaluronate plus rehabilitation exercise in patients with ankle OA.” PMID 24502534 Feb 2014

“Botulinum toxin type-A (BoNT-A) is often used for refractory cases unresponsive to conservative therapies; however, its biological mechanisms remain unclear.” PMID 42062988 Apr 2026

“Botulinum toxin A (BoNT-A) injection is one of the most widely used methods for hemifacial spasm (HFS) with high efficacy in controlling spasm.” PMID 27431279 Jul 2016

“OBJECTIVE: To assess the efficacy of intradermally injected botulinum neurotoxin type A (BoNT/A) in patients with Restless Legs Syndrome (RLS).” PMID 23063302 Oct 2012

“The ideal dosage for botulinum toxin type A (BoNT-A), a sphincter-preserving substitute for lateral internal sphincterotomy, is still unknown.” NCT07543315

“Botulinum Toxin-A (BoNT-A) is an injectable neuromodulator produced by Clostridium Botulinum, a Gram-positive bacillus that causes Botulism.” NCT06203470

“Intramuscular injections of botulinum toxin A (BoNT-A) have shown an analgesic effect on LBP in two previous randomized controlled studies.” PMID 29141611 Nov 2017

“botulinum toxin (BoNT-A) interventions prospectively compared to find out the effect of BoNT-A injection on myofascial pain syndrome (MPS).” NCT06899438

“Intravesical onabotulinumtoxinA (BoNT-A) injection can relieve symptoms of interstitial cystitis/bladder pain syndrome (IC/BPS).” PMID 29331031 Jan 2018

“intramuscular injection of 100U botulinum toxin (BoNT-A) is a reasonable choice for the treatment of bladder overactivity in PD” NCT05997043

“Non-randomised studies assessing intrarectal botulinum toxin type A (BoNTA) injections for faecal incontinence are promising.” PMID 38128556 Dec 2023

“Botulinum toxin type A (BoNT-A) is an exotoxin released by the Gram-positive, anaerobic bacillus Clostridium botulinum” NCT03331913

“Intravesical botulinum toxin A (BoNT-A) has recently emerged as novel treatment for OAB refractory to antimuscarinics” NCT01167257

“Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)” NCT06293300

“At the moment Onabotulinum toxin A (BoNT-A) represents the only drug specifically approved for CM prophylaxis.” NCT04578782

“Botulinum Neurotoxin A (BoNT-A) Injections will administered directly into the bulk of the muscles” NCT06218316

“Botulinum toxin A (BoNT-A) is used as an alternative treatment for chronic orthopedic conditions.” PMID 22673486 Jul 2012

“Botulinum toxin A (BoNT-A) is a novel treatment for chronic lateral epicondylar tendinopathy.” PMID 29762276 May 2018

“Botulinum toxin type A (BoNT-A) has shown potential in relieving chronic muscular pain.” PMID 41487935 Dec 2025

“Encouraging results were reported with the use of botulinum neurotoxin-A (BoNT-A).” PMID 26808752 Sep 2016

“injection of onabotulinumtoxinA 100 U (BoNT-A, Allergan, Irvine, California, USA)” NCT01657409

BoNT-A (Botox) 200 U will be injected into the detrusor (bladder wall muscle).” NCT06793683

“Ultrasound-Guided Botulinum Toxin Type A (BoNT-A) Salivary Gland Injection” NCT07070817

“botulinum toxin type A (BoNT-A) on cervical dystonia (CD) motor symptoms” PMID 23604344 Apr 2013

“Botulinum Neurotoxin Type A (BoNT-A) prostatic injection” PMID 29383480 Jan 2018

“Drug: Botulinum Toxin Type A (BoNT-A)” NCT07626983

“Botulinum Toxin Type A (BoNT-A)” NCT07645456

“botulinum toxin type A (BoNT/A)” NCT00451191

“botulinum toxin type A(BoNT-A)” NCT01276015

“Botulinum toxin A (BoNT-A) 50U” NCT02425176

“Botulinum toxin type A, BoNT-ANCT00945295

“Botulinum toxin A ( BoNT-A)” NCT02832713

NCT01275521

NCT02427646

NCT02505802

NCT05411900

NCT07426640

NCT06225024

Known as BoNT-A (BOTOX 300U) BoNT-A (BOTOX 300U)NCT01682603
Known as BoTN “STUDY QUESTION: Does the depth of injection of onabotulinumtoxinA neurotoxin in the glabellar complex affect efficacy of the BoTN for the improvement of glabellar frown lines?” NCT05766683