The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD)

Phase 4 Completed 250 enrolled Arteriogenesis Competence Network

RandomizedParallel-groupTriple-blindTreatment

Summary

To evaluate the change in walking capacity after a well organized and structured intensive physical training program with supportive pharmacotherapy with Clopidogrel or ASA. It is hypothesized that statistically superior results will emerge from a structured training supported by Clopidogrel as compared to a structured training supported by ASA.

Timeline

Start: 2005-05
Primary completion: 2008-04
Completion: 2008-06

Publications

Singer E, Imfeld S, Staub D, Hoffmann U, Buschmann I, Labs KH, Jaeger KA. Effect of aspirin versus clopidogrel on walking exercise performance in intermittent claudication-a double-blind randomized multicenter trial. J Am Heart Assoc. 2012 Feb;1(1):51-6. doi: 10.1161/JAHA.111.000067. Epub 2012 Feb 20.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Aspirin	Small molecule	100 mg	Oral
Comparator	Clopidogrel	Small molecule	75 mg	Oral

The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD)

Summary

Timeline

Publications

Drugs

Indications