drugset / Trial / NCT00192595
Tenofovir in HIV/HBV Coinfection
Phase 4
Completed
36 enrolled
Kirby Institute
Gilead Sciences · collabThe University of New South Wales · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of the study is to compare the effectiveness of 3 different treatment regimens in reducing or clearing the Hepatitis B Virus in patients infected with HIV and Hepatitis B (co-infection)
Timeline
- Start
- 2004-01
- Primary completion
- 2007-01
- Completion
- 2007-01
Publications
- Avihingsanon A, Matthews GV, Lewin SR, Marks P, Sasadeusz J, Cooper DA, Bowden S, Locarnini S, Dore GJ, Ruxrungtham K. Assessment of HBV flare in a randomized clinical trial in HIV/HBV coinfected subjects initiating HBV-active antiretroviral therapy in Thailand. AIDS Res Ther. 2012 Mar 9;9(1):6. doi: 10.1186/1742-6405-9-6.
- Matthews GV, Avihingsanon A, Lewin SR, Amin J, Rerknimitr R, Petcharapirat P, Marks P, Sasadeusz J, Cooper DA, Bowden S, Locarnini S, Ruxrungtham K, Dore GJ. A randomized trial of combination hepatitis B therapy in HIV/HBV coinfected antiretroviral naive individuals in Thailand. Hepatology. 2008 Oct;48(4):1062-9. doi: 10.1002/hep.22462.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Lamivudine | Other / unclassified | — | — |
| Subject | Tenofovir | Small molecule | — | — |
| Comparator | Efavirenz | Other / unclassified | — | — |
| Comparator | Zidovudine | Small molecule | — | — |