Zidovudine
Regulatory milestones approvals, filings & regulatory actions · 9 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansions (7) | US (FDA) | RETROVIR | — | 1990-01-12 – 2009-11-06 | fda.gov ↗ |
| Approved | EU (EMA) | Combivir | — | 1998-03-18 | europa.eu ↗ |
| Approved | US (FDA) | RETROVIR | — | 1987-03-19 | fda.gov ↗ |
Trials 274 · started per year
Also used as a comparator or background therapy in 133 trials
Evidence & citations 12 cited values
Every value below carries the sentence it was read from. 417 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Zidovudine | “Generic names: Efavirenz/Emtricitabine/Tenofovir, Lamivudine/Zidovudine, Emtricitabine, Lamivudine, Abacavir/Lamivudine, Zidovudine, Abacavir/Lamivudine/Zidovudine,...” NCT00624195 ↗408“It may include one or two nucleoside reverse transcriptase inhibitors, such as zidovudine, didanosine, lamuvidine, zalcitabine, stavudine), a non- nucleoside reverse...” NCT00032669 ↗ “Additional ARVs provided for use in this study included fixed dose combination lamivudine/zidovudine (3TC/ZDV), lamivudine (3TC), zidovudine (ZDV), tenofovir (TDF), fixed dose...” NCT00955968 ↗ “Participants will receive 2 investigator-selected NRTIs, which may include abacavir (ABC), lamivudine (3TC)/zidovudine (ZDV), didanosine (DDI), emtricitabine (FTC), ABC/3TC,...” NCT01363011 ↗ “NRTIs included abacavir, emtricitabine, Combivir (lamivudine/zidovudine, coformulated), Epzicom (abacavir/lamivudine, coformulated), lamivudine, stavudine, tenofovir DF,...” NCT01252940 ↗ “Investigator selected 2 NRTIs: (1) Zidovudine and lamivudine (Combivir) and (2) tenofovir disoproxil fumarate and emtricitabine (Truvada) will be administered as per the...” NCT00110305 ↗ “These study will explore how fast NVP is eliminated from women after delivery and to see if given zidovudine/lamivudine (AZT/3TC) for 1 or 2 weeks after NVP discontinuation can...” NCT00872872 ↗ “Children initiated ART using an induction-maintenance approach, starting with open-label four-drug lamivudine, abacavir, NNRTI, plus zidovudine for 36 weeks, then open-label...” NCT02028676 ↗ “For those subjects in South Africa and Argentina who were previously receiving Combivir along with maraviroc in Study A4001026, Combivir will be supplied as tablets containing...” NCT01776996 ↗ “Participants who will be enrolled in this trial would keep their previous combined antiretroviral therapy, such as zidovudine or stavudine plus lamivudine plus nevirapine or efavirenz.” NCT02002286 ↗ “NRTIs may include emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF), zidovudine+FTC/TDF, abacavir (ABC)+TDF, ABC+FTC/TDF, ABC+lamivudine (3TC), or didanosine (DDI)+FTC.” NCT01440569 ↗ “receive abacavir sulfate/lamivudine/zidovudine (ABC/3TC/ZDV) twice-daily or atazanavir (ATV) once-daily plus lamivudine/zidovudine (3TC/ZDV) twice-daily.” PMID 19358725 ↗ Apr 2009 “One hundred subjects in Russia will be treated with a combination of Combivir (zidovudine and lamivudine) and maraviroc as their first line HIV therapy.” NCT01275625 ↗ “For intolerance to Truvada, Combivir (zidovudine 300mg/lamivudine 150mg)will be available to be taken as 1 PO BID.” NCT00949234 ↗ “Zidovudine (ZDV, Retrovir®) 10 mg/ml oral syrup administered twice daily at WHO weight band dose for 48 weeks” NCT01818258 ↗ “Trizivir® is a combination of three antiretroviral agents: Abacavir, Lamivudine and Zidovudine in a tablet.” NCT00865475 ↗ “patients who currently successfully use zidovudine (AZT) and lamivudine (3TC) as part of their regimen” NCT00389194 ↗ “zidovudine, lamivudine, nevirapine or zidovudine, lamivudine if their mother is infected with HIV-2” NCT03642704 ↗ “Optimized NRTI recycling with lamivudine and one other NRTI (zidovudine or tenofovir or abacavir)” NCT03602690 ↗ “women received antenatal zidovudine and peripartum nevirapine, the standard of care at the time.” PMID 23324656 ↗ May 2013 “300 mg abacavir sulfate/150 mg lamivudine/300 mg zidovudine tablet taken orally twice daily” NCT00270296 ↗ “The second NRTI will be zidovudine unless the participant has a hemoglobin < 8 gm/dL” NCT00978068 ↗ “either zidovudine 300 mg BID if hemoglobin is ≥ 8 g/L or stavudine 30 mg BID” NCT01192035 ↗ “HAART: The first line was Zidovudine(AZT)+Lamivudine(3TC)+Efavirenz(EFV)” NCT01344148 ↗ “In the arms with NRTIs, 86% of patients received zidovudine/lamivudine.” PMID 19363330 ↗ Apr 2009 “both in combination with zidovudine/lamivudine 300/150 mg twice daily” PMID 23782005 ↗ Jul 2013 “Combivir® (lamivudine (LAM)/zidovudine (ZDV) coformulated)” NCT00708162 ↗ “lamivudine 150 mg plus zidovudine 300 mg BID dosed orally” NCT00246610 ↗ “Zidovudine 300mg and lamivudine 150mg BID for 6 months” NCT00490620 ↗ “containing tenofovir, zidovudine and lamivudine” NCT00356616 ↗ “AZT/3TC/NVP (zidovudine/lamivudine/nevirapine)” NCT00428116 ↗ “zidovudine 300 mg orally three times a day” NCT03922724 ↗ “zalcitabine (ddC), zidovudine (AZT)” NCT00039741 ↗ “zidovudine (ZDV or AZT)” NCT03631732 ↗ “zidovudine or stavudine” NCT01075152 ↗ “Zidovudine (300 mg)” NCT01605084 ↗ “zidovudine (ZDV)” NCT00006617 ↗ “zidovudine (ZDV)” NCT02016924 ↗ “Zidovudine (AZT)” NCT02231281 ↗ “zidovudine (ZDV)” NCT06337032 ↗ “Zidovudine” NCT02231281 ↗ “zidovudine” NCT01637259 ↗ |
| Known as | 3'-Azido-3'-Deoxythymidine | “Phase I Trial of the Combination of 3'-Azido-3'-Deoxythymidine (Zidovudine) and Recombinant Interleukin-2” NCT00001005 ↗ |
| Known as | Azidothymidine | “The purpose of this study is to see if giving azidothymidine (AZT) to HIV-positive patients with hemophilia is safe and if it is effective in lowering HIV levels and boosting...” NCT00000705 ↗2“A Clinical Study Examining the Pharmacokinetics and Bioavailability of Azidothymidine (AZT, Zidovudine) in Patients With Human Immunodeficiency Virus (HIV) Infection and Hepatic Disease” NCT00001001 ↗ “Study of Bleeding Tendency, Platelet Function, and Pharmacokinetics of Azidothymidine (AZT) and Motrin (Ibuprofen) in HIV-Infected Hemophiliacs” NCT00002276 ↗ |
| Known as | AZT | “To evaluate the effect of anti-HIV immune serum globulin (HIVIG) versus immune globulin (IVIG) administered during pregnancy and to the newborn, in combination with zidovudine...” NCT00000751 ↗171“To determine if alternating zidovudine (AZT) and zalcitabine (dideoxycytidine; ddC) (first one and then the other) or intermittent therapy (1 week of drug then 1 week off) will...” NCT00000718 ↗ “The purpose of this study is to determine the short term safety, tolerance, and antiviral effect of zidovudine (AZT) and amdoxovir (AMDX, DAPD) in combination, and whether the...” NCT00432016 ↗ “To compare the effectiveness of zalcitabine ( dideoxycytidine; ddC ) therapy to zidovudine ( AZT ) in the treatment of AIDS or advanced AIDS related complex ( ARC ) in patients...” NCT00000678 ↗ “The investigators propose to evaluate the safety of combination therapy comprising the three nucleoside analog reverse-transcriptase inhibitors (NRTIs) zidovudine (AZT),...” NCT02363452 ↗ “To compare the efficacy of lamivudine (3TC) and zidovudine (AZT) in combination versus the better of didanosine (ddI) monotherapy or ddI/AZT combination, in symptomatic HIV-1...” NCT00001066 ↗ “To determine if the pharmacokinetics of low doses of zidovudine (AZT) (that is, how fast AZT reaches the blood, what concentration of AZT is attained in the blood, and how long...” NCT00000732 ↗ “Preliminary studies using human liver tissue have shown that valproic acid inhibits the metabolic inactivation of zidovudine (AZT), which may prolong the plasma half-life of...” NCT00000629 ↗ “To determine the effects of zidovudine (AZT) alone and in combination with didanosine (ddI) on viral load in the lymphoid tissue and blood of antiretroviral-naive, HIV-infected...” NCT00001057 ↗ “To evaluate the anti-HIV effect of single agent versus combination therapy with zidovudine (AZT) and interferon alfa-2a (IFN-A2a), as measured by p24 protein expression, viral...” NCT00000696 ↗ “Primary: To compare the efficacy of zidovudine ( AZT ) given alone versus AZT plus didanosine ( ddI ) versus AZT plus zalcitabine ( dideoxycytidine; ddC ) in delaying the...” NCT00001022 ↗ “The purpose of this study is to see if nevirapine (NVP) or zidovudine (AZT), given to mothers during labor and delivery and to their babies during the first week of life, can...” NCT00006396 ↗ “To determine the safety and efficacy of two doses of interferon alfa-2a ( IFN alfa-2a ) in combination with zidovudine ( AZT )/zalcitabine ( ddC ) versus AZT/ddC only in...” NCT00000754 ↗ “These study will explore how fast NVP is eliminated from women after delivery and to see if given zidovudine/lamivudine (AZT/3TC) for 1 or 2 weeks after NVP discontinuation can...” NCT00872872 ↗ “A Randomized, Double-Blind, Phase III Study of Indinavir Sulfate With Open-Label Zidovudine (AZT) and Lamivudine (3TC) in Subjects With HIV Infection With CD4 Cell Counts <=...” NCT00000841 ↗ “A Pilot Study to Evaluate the Immunologic Consequences of a Highly Active Antiretroviral Therapy Regimen (HAART) Consisting of Ritonavir (ABT-538), Zidovudine (AZT), and...” NCT00001075 ↗ “To evaluate the short-term effects of administering zidovudine ( AZT ) at the same time with increasing doses of aldesleukin ( interleukin-2; IL-2 ) in patients with persistent...” NCT00000728 ↗ “To show that zalcitabine (dideoxycytidine; ddC) is at least as effective as zidovudine (AZT) in the treatment of AIDS or advanced AIDS related complex (ARC), and also that ddC...” NCT00000679 ↗ “A Phase I Study to Evaluate the Pharmacokinetics, Safety and Antiviral Effects of Concurrent Administration of Zidovudine (AZT) and 2'3'-Dideoxyinosine (ddI) in Patients With...” NCT00002014 ↗ “An Open-Label, Non-Comparative Study of Saquinavir-SGC in Combination With Zidovudine (AZT) and Lamivudine (3TC) in the Treatment of HIV-1 Infected Patients With No Previous...” NCT00002367 ↗ “A Double-Blind Comparison of Zidovudine (AZT) Versus Stavudine (d4T; BMY 27857) for the Treatment of Patients With HIV Infection Who Have Absolute CD4 Lymphocyte Counts Between...” NCT00002307 ↗ “Forty patients currently taking zidovudine (AZT) or any other approved antiretroviral agent will be randomized to one of three treatment arms: high-dose nimodipine, low-dose...” NCT00000738 ↗ “To evaluate the safety and effectiveness of Retrovir (AZT) when used as prophylaxis for health care workers at risk for HIV infection from exposure to HIV-contaminated blood or...” NCT00002287 ↗ “The purpose of this study is to see if giving azidothymidine (AZT) to HIV-positive patients with hemophilia is safe and if it is effective in lowering HIV levels and boosting...” NCT00000705 ↗ “To study the use of acyclovir (ACV) and zidovudine (AZT) in the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS who would otherwise be treated with...” NCT00000693 ↗ “zidovudine ( AZT ) versus didanosine ( ddI ), AZT plus ddI, and AZT plus zalcitabine ( ddC ) in preventing disease progression in HIV-infected patients with CD4 counts of...” NCT00000625 ↗ “To determine if methadone treatment will affect the blood levels of zidovudine (AZT) in patients with AIDS or AIDS-related complex (ARC) who are receiving oral AZT and...” NCT00001008 ↗ “A Clinical Study Examining the Pharmacokinetics and Bioavailability of Azidothymidine (AZT, Zidovudine) in Patients With Human Immunodeficiency Virus (HIV) Infection and Hepatic Disease” NCT00001001 ↗ “To compare the effect of stavudine (d4T) alone or with zidovudine (AZT) versus didanosine (ddI) alone or with AZT on CD4 counts, HIV RNA levels, and viral load in HIV-infected patients” NCT00001063 ↗ “To evaluate the safety and efficacy of low and high doses of lamivudine ( 3TC ) in combination with zidovudine ( AZT ) and zalcitabine ( dideoxycytidine; ddC ) in combination with AZT.” NCT00002436 ↗ “treatment with zidovudine (AZT) will delay or prevent the onset of AIDS or AIDS related complex (ARC) in individuals infected with HIV but who do not have symptoms of AIDS or ARC.” NCT00000736 ↗ “To evaluate the safety and efficacy of interferon beta (Betaseron) in AIDS and advanced AIDS related complex (ARC) patients receiving a reduced-dose zidovudine (AZT) regimen.” NCT00002238 ↗ “To prevent individuals who have had a massive accidental exposure to HIV from becoming infected with HIV and possibly developing AIDS, by treating them with zidovudine (AZT).” NCT00000993 ↗ “To determine the safety and effectiveness of combining zidovudine (AZT) and interferon alfa-2a (IFN-A2a) in a treatment for Kaposi's sarcoma (KS) in patients who have AIDS.” NCT00000687 ↗ “To evaluate and compare differences in tolerance and side effects associated with two different dosages of zidovudine (AZT) when used to treat children with HIV infection.” NCT00000983 ↗ “To determine whether there is a pharmacokinetic drug interaction between oral ganciclovir and oral zidovudine (AZT) and between oral ganciclovir and oral didanosine (ddI).” NCT00002096 ↗ “To define the pharmacokinetic parameters (blood levels) of total phosphorylated zidovudine (AZT) in peripheral blood mononuclear cells (PBMC) from HIV-infected patients.” NCT00000965 ↗ “A Pilot Study To Evaluate the Effect of Retrovir (Zidovudine: AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Associated Dementia and Neuromuscular Diseases” NCT00002044 ↗ “To determine the safety and usefulness of zidovudine (AZT) for the treatment of patients with early symptomatic HIV infection or early AIDS related complex (ARC).” NCT00001011 ↗ “To determine the safety and tolerance of hyperimmune anti-HIV intravenous immunoglobulin (HIVIG) and of zidovudine (AZT) in infants with established HIV infection” NCT00000961 ↗ “treatment with zidovudine (AZT) compared to didanosine (ddI) and compared to the combination of AZT and ddI as determined by survival and disease progression” NCT00000637 ↗ “A Randomized, Open-Label Study of Alternative Treatment Combinations of Dideoxycytidine (HIVID; ddC) and Zidovudine (AZT) in Patients With HIV Infection” NCT00002117 ↗ “A Phase III Study to Evaluate the Safety, Tolerance, and Efficacy of Early Treatment With Zidovudine (AZT) in Asymptomatic Infants With HIV Infection” NCT00000750 ↗ “To evaluate the safety and tolerance of oral zidovudine (AZT) when given over a period of 24 weeks to children between 3 months and 12 years of age.” NCT00000716 ↗ “To determine the pharmacokinetics, safety, and efficacy of didanosine (ddI) alone or in combination with zidovudine (AZT) in HIV-infected infants.” NCT00001049 ↗ “Patients that are included are HIV infected and have started zidovudine (AZT) or didanosine (ddI) at least 4 weeks before entry into this study.” NCT00000971 ↗ “Study of Bleeding Tendency, Platelet Function, and Pharmacokinetics of Azidothymidine (AZT) and Motrin (Ibuprofen) in HIV-Infected Hemophiliacs” NCT00002276 ↗ “interactive effects of didanosine ( ddI ) or zalcitabine ( dideoxycytidine; ddC ) with zidovudine ( AZT ) on the pharmacokinetics of U-87201E” NCT00000753 ↗ “A Randomized, Comparative Trial of Zidovudine (AZT) Versus 2',3'-Didehydro-3'-Deoxythymidine (Stavudine; d4T) in Children With HIV Infection” NCT00000789 ↗ “Specifically, to evaluate zidovudine/zalcitabine ( AZT / ddC ) alone or in combination with either nevirapine or saquinavir ( Ro 31-8959 ).” NCT00002347 ↗ “Zidovudine (AZT) has previously demonstrated its effectiveness as a potent inhibitor of HIV replication in vitro and in adult patients” NCT00001106 ↗ “Open-Label Program of Dideoxycytidine ( ddC ) to Be Used in Combination With Zidovudine ( AZT ) for Treatment of Advanced HIV Disease” NCT00002081 ↗ “To determine the safety and tolerance of low-dose versus high-dose cysteamine administered concurrently with zidovudine (AZT).” NCT00002110 ↗ “To assess the safety and tolerance of the combination of zidovudine (AZT) and didanosine (ddI) in children with HIV infection.” NCT00000652 ↗ “The duration of clinical benefit from zidovudine (AZT) may be limited because of development of viral resistance to the drug.” NCT00000814 ↗ “To determine the safety and anti-HIV activity of two doses of SC-49483 in combination with zidovudine (AZT) versus AZT alone.” NCT00000791 ↗ “safety, tolerance, and pharmacokinetics of zidovudine (AZT) and zalcitabine (dideoxycytidine; ddC) when given in combination” NCT00001032 ↗ “An Open Trial of Zidovudine (AZT) Treatment of the AIDS Dementia Complex in Patients With AIDS or Low CD4+ Lymphocyte Counts” NCT00000709 ↗ “PRIMARY: To determine the maximum tolerated dose of interferon-alfa (IFN-A) alone and in combination with zidovudine (AZT)” NCT00000967 ↗ “The Safety and Effectiveness of Zidovudine (AZT) in the Treatment of HIV Infection in Patients With AIDS and Advanced ARC” NCT00000999 ↗ “nevirapine administered in combination with zidovudine (AZT) in mildly to moderately symptomatic HIV-infected children” NCT00001111 ↗ “To determine the safety and usefulness of zidovudine (AZT) for the treatment of children 3 months to 12 years of age.” NCT00000990 ↗ “Safety of Reduced Dose Zidovudine (AZT) Compared With Standard Dose AZT in Antiretroviral-naïve HIV-infected Patients” NCT01540240 ↗ “To test whether zidovudine (AZT) is useful as a treatment for the neurologic syndrome called AIDS dementia complex.” NCT00000702 ↗ “high-dose systemic methotrexate (MTX) and dexamethasone (DEX) combined with zidovudine (AZT) and brain irradiation” NCT00000723 ↗ “combination therapy for AIDS-associated Kaposi's sarcoma with zidovudine (AZT) and two kinds of interferon alpha” NCT00001113 ↗ “To evaluate the feasibility of Retrovir (AZT) in the treatment of psoriasis in HIV antibody positive patients.” NCT00002286 ↗ “To determine how zidovudine (AZT) for the treatment of HIV infection is metabolized and excreted or eliminated” NCT00000685 ↗ “To determine whether there is any additive toxicity with combined use of sCD4-PE40 and zidovudine (AZT).” NCT00000743 ↗ “patients who currently successfully use zidovudine (AZT) and lamivudine (3TC) as part of their regimen” NCT00389194 ↗ “chronic administration of Retrovir (AZT) to adult patients with early manifestations of HIV disease.” NCT00002045 ↗ “efficacy, safety, and pharmacokinetics of lamivudine (3TC) combined with zidovudine (AZT), stavudine” NCT00000838 ↗ “low-, moderate-, and high-dose schedules of zidovudine (AZT) plus didanosine (ddI) versus ddI alone” NCT00000656 ↗ “with or without daily oral zidovudine (AZT) or their current stable dose of antiretroviral therapy.” NCT00000755 ↗ “intravenous (IV) and oral zidovudine (AZT) can be safely given to children aged 1 day to 3 months” NCT00001007 ↗ “To determine the relationship of viral susceptibility to zidovudine (AZT) and baseline viral load” NCT00001025 ↗ “Combination Zidovudine (AZT) and 9-(2-Phosphonylmethoxyethyl)Adenine (PMEA; Adefovir) Treatment” NCT00002326 ↗ “combined administration of zidovudine (AZT) and increasing doses of recombinant interleukin-2” NCT00001005 ↗ “These treatments include zidovudine (AZT), which has been shown to control the HIV infection” NCT00001112 ↗ “To determine whether methadone maintenance alters the pharmacokinetics of zidovudine (AZT).” NCT00000800 ↗ “Patients continue to receive AZT at the dose prescribed prior to enrollment in the study.” NCT00000973 ↗ “Zidovudine (AZT) Versus AZT Plus Didanosine (ddI) Versus AZT Plus ddI Plus Nevirapine” NCT00001045 ↗ “concurrent oral Retrovir / Zovirax (AZT and ACV) therapy and oral AZT therapy alone” NCT00002290 ↗ “Primary: To determine the clinical effect of zidovudine (AZT) compared to placebo” NCT00002063 ↗ “Zidovudine (AZT) is administered orally 3 times daily at one of two dose levels.” NCT00000976 ↗ “compare the effectiveness and toxicity of didanosine (ddI) and zidovudine (AZT)” NCT00000671 ↗ “regimens of zidovudine ( AZT ) and 2',3'-dideoxycytidine ( zalcitabine; ddC )” NCT00000719 ↗ “combined oral zidovudine (AZT) and intermittent intravenous foscarnet therapy” NCT00001002 ↗ “Combivir (Zidovudine (AZT) plus lamivudine (3TC)) and nevirapine twice a day;” NCT00143689 ↗ “continuous oral zidovudine (AZT) treatment to HIV infected pregnant women” NCT00000960 ↗ “HAART: The first line was Zidovudine(AZT)+Lamivudine(3TC)+Efavirenz(EFV)” NCT01344148 ↗ “taking zidovudine (AZT) will change the natural course of HIV infection” NCT00000994 ↗ “high doses of zidovudine (AZT) (that is, how fast AZT reaches the blood” NCT00000734 ↗ “multiple oral doses of nevirapine in combination with zidovudine (AZT)” NCT00000649 ↗ “safety, tolerability, and activity of zidovudine (AZT) and zalcitabine” NCT00000978 ↗ “patients who have been taking zidovudine (AZT) alone for a long time” NCT00000831 ↗ “The study is designed to test the drug zidovudine (AZT) in children” NCT00000701 ↗ “zidovudine ( AZT ) and didanosine ( ddI ) alone and in combination” NCT00000823 ↗ “ganciclovir (GCV) and zidovudine (AZT) when given in combination.” NCT00000995 ↗ “To evaluate the interaction of probenecid with zidovudine (AZT).” NCT00000670 ↗ “combination of nevirapine and zidovudine (AZT) versus AZT alone” NCT00002323 ↗ “abacavir sulfate (ABC), lamivudine (3TC), and zidovudine (AZT)” NCT00084149 ↗ “Arm 1: Zidovudine (AZT), emtricitabine (FTC), efavirenz (EFV)” NCT00127959 ↗ “together with one of two different doses of zidovudine (AZT).” NCT00000987 ↗ “combination chemotherapy-radiation-zidovudine (AZT) treatment” NCT00000703 ↗ “zidovudine (AZT) and various doses of cancer-fighting drugs” NCT00000681 ↗ “zidovudine (AZT) plus AS-101 versus AZT alone (placebo arm)” NCT00002033 ↗ “Zidovudine (AZT) 600 mg orally q6 hours (every 6 hours)” NCT01441063 ↗ “when it is given at the same time as zidovudine (AZT)” NCT00000695 ↗ “in combination with zidovudine (AZT) versus AZT alone” NCT00002269 ↗ “Zidovudine (AZT), lamivudine (LAM), efavirenz (EFV)” NCT00192595 ↗ “of zidovudine (AZT) administered daily for 48 weeks” NCT00002020 ↗ “short-course zidovudine (AZT) and lamivudine (3TC)” PMID 19859531 ↗ Oct 2009 “continuous intravenous ( CIV ) zidovudine ( AZT )” NCT00002263 ↗ “Abacavir (ABC)+Lamivudine (3TC)+Zidovudine (AZT)” NCT04731103 ↗ “either zidovudine ( AZT ) or didanosine ( ddI )” NCT00000810 ↗ “AZT/3TC/NVP (zidovudine/lamivudine/nevirapine)” NCT00428116 ↗ “AZT/3TC/NVP (zidovudine/lamivudine/nevirapine)” NCT00427297 ↗ “Combivir (zidovudine [AZT] / lamivudine [3TC])” NCT00192621 ↗ “associated with zidovudine ( AZT ) treatment” NCT00002007 ↗ “antiretroviral effects of zidovudine (AZT)” NCT00000647 ↗ “concurrent treatment with zidovudine (AZT)” NCT00002034 ↗ “zidovudine ( AZT ) plus didanosine (ddI)” NCT00000781 ↗ “Retrovir Brand Zidovudine (AZT) Therapy” NCT00000662 ↗ “Zidovudine (AZT) & Interleukin-2 (IL2)” NCT00001282 ↗ “dose of zidovudine (AZT) that was used” NCT00000700 ↗ “between zidovudine (AZT) and oxazepam” NCT00000661 ↗ “orally administered zidovudine (AZT)” NCT00002035 ↗ “orally administered zidovudine (AZT)” NCT00000657 ↗ “zidovudine (AZT) is used by the body” NCT00000706 ↗ “patients receiving zidovudine (AZT)” NCT00000680 ↗ “zalcitabine (ddC), zidovudine (AZT)” NCT00039741 ↗ “Combivir (Zidovudine or AZT + 3TC)” NCT01088516 ↗ “zidovudine (AZT) versus didanosine” NCT00001997 ↗ “stable dose of zidovudine ( AZT )” NCT00002312 ↗ “zidovudine (AZT) plus zalcitabine” NCT00001029 ↗ “fixed doses of Zidovudine (AZT)” NCT00002322 ↗ “Interleukin-2/Zidovudine (AZT)” NCT00001354 ↗ “oral dose of zidovudine (AZT)” NCT00002023 ↗ “Zidovudine (AZT) Monotherapy” NCT00002320 ↗ “daily oral zidovudine (AZT)” NCT00001036 ↗ “zidovudine (AZT) treatment” NCT00000818 ↗ “Zidovudine (AZT) 300mg bid” NCT00618176 ↗ “low-dose Zidovudine (AZT)” NCT00001993 ↗ “zidovudine (AZT) therapy” NCT00000711 ↗ “zidovudine (ZDV or AZT)” NCT03631732 ↗ “zidovudine (AZT) alone” NCT00000712 ↗ “Drug: Zidovudine (AZT)” NCT00002524 ↗ “oral zidovudine (AZT)” NCT00000720 ↗ “plus zidovudine (AZT)” NCT00000991 ↗ “with zidovudine (AZT)” NCT00000725 ↗ “oral zidovudine (AZT)” NCT00000664 ↗ “zidovudine (AZT) IV” NCT00006264 ↗ “zidovudine ( AZT )” NCT00001067 ↗ “zidovudine ( AZT )” NCT00002357 ↗ “Zidovudine ( AZT )” NCT00000803 ↗ “zidovudine (AZT)” NCT00000731 ↗ “Zidovudine (AZT)” NCT00002270 ↗ “Zidovudine (AZT)” NCT00002281 ↗ “Zidovudine (AZT)” NCT00002155 ↗ “Zidovudine (AZT)” NCT00002443 ↗ “Zidovudine (AZT)” NCT00002334 ↗ “zidovudine (AZT)” NCT00005000 ↗ “zidovudine (AZT)” NCT00002013 ↗ “Zidovudine (AZT)” NCT02231281 ↗ “zidovudine (AZT)” NCT00000770 ↗ “zidovudine (AZT)” NCT00001040 ↗ “zidovudine (AZT)” NCT00000628 ↗ “zidovudine (AZT)” NCT00000742 ↗ “Zidovudine (AZT)” NCT00002255 ↗ “zidovudine (AZT)” NCT00002124 ↗ “zidovudine; AZT” NCT00002435 ↗ |
| Known as | Retrovir | “100 patients will be randomized to receive Zerit (Stavudine) + Epivir (Lamivudine) + Crixivan (Indinavir) and 100 patients will be randomized to receive Retrovir (Zidovudine) +...” NCT00002369 ↗8“A Multi-Center, Double-Blind Trial to Evaluate the Safety and Efficacy of Concurrent Retrovir (Zidovudine) and Zovirax (Acyclovir) Therapy in Patients With Early Symptomatic...” NCT00002290 ↗ “To evaluate the safety and effectiveness of Retrovir (AZT) when used as prophylaxis for health care workers at risk for HIV infection from exposure to HIV-contaminated blood or...” NCT00002287 ↗ “A Pilot Study To Evaluate the Effect of Retrovir (Zidovudine: AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Associated Dementia and Neuromuscular Diseases” NCT00002044 ↗ “To evaluate the feasibility of Retrovir (AZT) in the treatment of psoriasis in HIV antibody positive patients.” NCT00002286 ↗ “chronic administration of Retrovir (AZT) to adult patients with early manifestations of HIV disease.” NCT00002045 ↗ “300 mg zidovudine (Retrovir tablets, GlaxoSmithKline)” NCT00966160 ↗ “Retrovir Brand Zidovudine (AZT) Therapy” NCT00000662 ↗ “Retrovir (Zidovudine)” NCT00002168 ↗ |
| Known as | Retrovir(R) | “Zidovudine, or Retrovir(R), is used at a high dose.” NCT00092222 ↗ |
| Known as | ZCV | “Zidovudine (ZCV)” NCT00144183 ↗ |
| Known as | ZDV | “Additional ARVs provided for use in this study included fixed dose combination lamivudine/zidovudine (3TC/ZDV), lamivudine (3TC), zidovudine (ZDV), tenofovir (TDF), fixed dose...” NCT00955968 ↗67“Participants will receive 2 investigator-selected NRTIs, which may include abacavir (ABC), lamivudine (3TC)/zidovudine (ZDV), didanosine (DDI), emtricitabine (FTC), ABC/3TC,...” NCT01363011 ↗ “The purpose of this study is to see if it is safe to give saquinavir-SGC (SQV) combined with low-dose ritonavir (RTV) plus zidovudine (ZDV) and lamivudine (3TC) to HIV-positive...” NCT00000920 ↗ “A Double-Blind, Randomized, Multicenter Trial to Evaluate the Safety and Efficacy of the Combination of 1592U89/Zidovudine (ZDV)/Lamivudine (3TC) Versus the Combination of...” NCT00002391 ↗ “The efficacy and tolerance of switching from zidovudine (ZDV) and lamivudine (3TC) in clinically stable HIV-infected children with incomplete viral suppression to stavudine...” PMID 11840078 ↗ Feb 2002 “Arm I options are enteric-coated didanosine (ddI-EC) plus lamivudine (3TC), ddI-EC plus zidovudine (ZDV), ZDV plus 3TC (or Combivir), stavudine (d4T) plus 3TC, or ddI-EC plus...” NCT00014937 ↗ “Double reverse transcriptase inhibitor (RTI) therapy consisting of any two therapy combinations of: didanosine (ddI), lamivudine (3TC), stavudine (d4T) or zidovudine (ZDV),...” NCT00002376 ↗ “The purpose of this study is to compare the safety and effectiveness of taking lamivudine (3TC) plus zidovudine (ZDV) plus a protease inhibitor (PI) with taking the 3TC/ZDV...” NCT00002203 ↗ “The purpose of this study is to see if it is safe and effective to give ritonavir (RTV) plus lamivudine (3TC) plus zidovudine (ZDV) to HIV-infected pregnant women during...” NCT00000888 ↗ “The extent and manner by which HIV nucleoside reverse transcriptase inhibitors contribute to insulin resistance is unclear. We evaluated the effect of zidovudine/lamivudine...” PMID 19898246 ↗ Feb 2010 “Treatment-naive adults were randomized to nevirapine (NVP) or ritonavir-boosted lopinavir (LPV/r) regimens each in combination with tenofovir (TDF)/emtricitabine (FTC) or...” PMID 25028911 ↗ May 2014 “A Phase I Trial of the Safety, Tolerance, and Pharmacokinetics of Oral Nelfinavir (Viracept) Co-Administered With Zidovudine (ZDV) and Lamivudine (3TC) in HIV Infected Pregnant...” NCT00000887 ↗ “A Randomized, Double Blind, Comparative Study of Dideoxycytidine (ddC) Alone or ddC/AZT Combination Versus Zidovudine (ZDV) Alone in Patients With HIV Infection Who Have...” NCT00000651 ↗ “Subjects (2 to <16 years) on a stavudine (d4T) or zidovudine (ZDV) containing regimen with HIV-1 RNA <400 copies/mL were randomized to either switch d4T or ZDV to TDF or...” PMID 25760565 ↗ Apr 2015 “A Phase II Study to Evaluate the Safety, Tolerance and Efficacy of Hyperimmune Anti-HIV Intravenous Immunoglobulin (HIVIG) and of Zidovudine (ZDV) in Infants With Documented...” NCT00000961 ↗ “The nucleoside analogue combinations provided on this study are as follows: zidovudine (ZDV) plus didanosine (ddI), ZDV plus lamivudine (3TC), stavudine (d4T) plus 3TC, or d4T plus ddI.” NCT00000923 ↗ “The purpose of this study is to look at the effects of different methods of birth control (oral and injectable) on how the body absorbs, makes available, and removes zidovudine (ZDV).” NCT00000897 ↗ “Patients receive specific combinations of 3 or 4 of the following 6 drugs: didanosine (ddI), stavudine (d4T) efavirenz (EFV), nelfinavir (NFV), lamivudine (3TC), or zidovudine (ZDV).” NCT00000919 ↗ “A sensitive LC/MS/MS assay for determining zidovudine (ZDV) and lamivudine (3TC) in human plasma was validated to support antiretroviral pharmacology research programs.” PMID 21465499 ↗ Apr 2011 “Patients receiving combination antiretroviral therapy with indinavir (IDV), zidovudine (ZDV)(or d4T) and lamivudine (3TC) show viral suppression for two years or more.” NCT00000916 ↗ “A Study to Test the Safety, Tolerance, and Metabolism of Abacavir (1592U89, ABC) With Standard Zidovudine (ZDV) Therapy in Newborn Infants Born to HIV-1 Infected Women” NCT00000864 ↗ “Study A: To determine whether treatment with zidovudine (ZDV) will delay or change the disease process in hemophilic patients who have HIV infection with no symptoms.” NCT00001104 ↗ “The purpose of this study is to examine the safety and tolerability of ZDV when given to premature infants born to HIV-positive women to prevent HIV infection.” NCT00000855 ↗ “300 mg of zidovudine (ZDV), 150 mg of lamivudine, and 200 mg nevirapine (NVP) was given twice daily from 34 weeks gestation until six months after delivery.” NCT00167674 ↗ “receive abacavir sulfate/lamivudine/zidovudine (ABC/3TC/ZDV) twice-daily or atazanavir (ATV) once-daily plus lamivudine/zidovudine (3TC/ZDV) twice-daily.” PMID 19358725 ↗ Apr 2009 “Most HIV-positive pregnant women usually take the anti-HIV drug zidovudine (ZDV) to treat HIV and reduce the chances of giving HIV to their babies.” NCT00000878 ↗ “A Feasibility Study of Lamivudine/Zidovudine (3TC/ZDV) Plus Efavirenz (EFV) as Initial Therapy of HIV-1 Infected Patients in a Rural Area of China” NCT00100594 ↗ “The two combinations are abacavir/lamivudine/zidovudine (ABC/3TC/ZDV) and zidovudine/lamivudine (ZDV/3TC) plus lopinavir/ritonavir (LPV/RTV).” NCT00086359 ↗ “Fixed dose combination abacavir/lamivudine/zidovudine (ABC/3TC/ZDV) among HIV-1 and tuberculosis (TB)-coinfected patients was evaluated” PMID 20001518 ↗ Dec 2009 “oral ZDV and to determine whether the oral administration of Zidovudine (ZDV) during labor and delivery will provide a similar profile” NCT00000862 ↗ “All patients will receive open label induction therapy with zidovudine (ZDV), lamivudine (3TC) and indinavir (IDV) for 6 months.” NCT00001084 ↗ “The combination of ZDV/3TC (Combivir®) and Lopinavir/ritonavir (LPV/r) (Kaletra® or Aluvia®) is chosen as a reference regimen” NCT00936195 ↗ “Arm A - 141W94, plus Zidovudine (ZDV) and Lamivudine (3TC) or Arm B - 141W94, plus ZDV placebo and 3TC placebo.” NCT00001085 ↗ “Zidovudine (ZDV, Retrovir®) 10 mg/ml oral syrup administered twice daily at WHO weight band dose for 48 weeks” NCT01818258 ↗ “Stavudine (d4T) + Lamivudine (3TC) + Zidovudine placebo or Zidovudine (ZDV) + Lamivudine + Stavudine placebo” NCT00002371 ↗ “Zidovudine (ZDV) and lamivudine (3TC) metabolism to triphosphates (TP) is necessary for antiviral activity.” PMID 17664328 ↗ Jul 2007 “The drugs to be used in combination with DLV are zidovudine (ZDV), indinavir (IDV), and lamivudine (3TC).” NCT00002401 ↗ “A Phase I Trial To Evaluate Zidovudine (ZDV) in HIV-1 Infected Pregnant Women and Their Offspring” NCT00001106 ↗ “tenofovir (TDF) + emtricitabine (FTC) + zidovudine (ZDV) + abacavir (ABC)” NCT00335322 ↗ “observational data suggest benefit from zidovudine (ZDV) therapy” NCT00099359 ↗ “abacavir (ABC)/lamivudine (3TC)/zidovudine (ZDV)/efavirenz (EFV)” NCT00013520 ↗ “ZDV (Zidovudine 300 mg) 1 tb BID (mornings and evenings orally)” NCT02150993 ↗ “those treated with zidovudine (ZDV) and those treated with ddI.” PMID 8229656 ↗ Nov 1993 “delavirdine (DLV) plus indinavir (IDV) plus zidovudine (ZDV)” NCT00002236 ↗ “Combivir® (lamivudine (LAM)/zidovudine (ZDV) coformulated)” NCT00708162 ↗ “zidovudine (ZDV), stavudine (D4T) and lamivudine (3TC)” NCT00001095 ↗ “indinavir plus lamivudine (3TC) plus zidovudine (ZDV)” NCT00000944 ↗ “DMP 266 plus zidovudine (ZDV) plus lamivudine (3TC)” NCT00002410 ↗ “lamivudine (3TC)/zidovudine (ZDV)/1592U89 arm” NCT00002199 ↗ “zidovudine (ZDV)-exposed uninfected children” PMID 25838291 ↗ Apr 2015 “oral zidovudine (ZDV) at the onset of labor” NCT00109590 ↗ “Lamivudine (3TC) and Zidovudine (ZDV)” NCT00002389 ↗ “zidovudine (ZDV or AZT)” NCT03631732 ↗ “Drug: Zidovudine (ZDV)” NCT02181933 ↗ “zidovudine (ZDV)” NCT02016924 ↗ “Zidovudine (ZDV)” NCT02249130 ↗ “Zidovudine (ZDV)” NCT01061151 ↗ “zidovudine (ZDV)” NCT00002386 ↗ “zidovudine (ZDV)” NCT00004736 ↗ “Zidovudine (ZDV)” NCT00158405 ↗ “Zidovudine (ZDV)” NCT00000865 ↗ “zidovudine (ZDV)” NCT00002208 ↗ “zidovudine (ZDV)” NCT06337032 ↗ “Zidovudine (ZDV)” NCT00142337 ↗ “Zidovudine (ZDV)” NCT00000882 ↗ “Zidovudine (ZDV)” NCT00002124 ↗ “zidovudine (ZDV)” NCT00006617 ↗ “Zidovudine (ZDV)” NCT00000891 ↗ |
| Known as | ZDV: zidovudine, azidothymidine, Retrovir | “ZDV: zidovudine, azidothymidine, Retrovir” NCT02028676 ↗ |
| Action | Inhibit | “previous studies have shown AZT to be an effective inhibitor of HIV reverse transcriptase” NCT00000695 ↗ |
| Modality | Small molecule | “nucleoside analog” NCT00000781 ↗ |
| Route | Oral | “AZT orally every 8 hours on days 1 through 4” NCT00000629 ↗ |